QQ客服 官方微博 反馈留言

	Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant streptococcus pneumoniae serotype 14
	Ding, Feng2,3; Tang, Petrus4; Hsu, Mei-Hua1; Cui, Peng2,3; Hu, Songnian2; Yu, Jun2; Chiu, Cheng-Hsun1
刊名	Bmc genomics
	2009-04-13
卷号	10页码:13
ISSN号	1471-2164
DOI	10.1186/1471-2164-10-158
通讯作者	Chiu, cheng-hsun(chchiu@adm.cgmh.org.tw)
英文摘要	Background: streptococcus pneumoniae serotype 14 is one of the most common pneumococcal serotypes that cause invasive pneumococcal diseases worldwide. serotype 14 often expresses resistance to a variety of antimicrobial agents, resulting in difficulties in treatment. to gain insight into the evolution of virulence and antimicrobial resistance traits in s. pneumoniae from the genome level, we sequenced the entire genome of a serotype 14 isolate (cgsp14), and carried out comprehensive comparison with other pneumococcal genomes. multiple serotype 14 clinical isolates were also genotyped by multilocus sequence typing (mlst). results: comparative genomic analysis revealed that the cgsp14 acquired a number of new genes by horizontal gene transfer (hgt), most of which were associated with virulence and antimicrobial resistance and clustered in mobile genetic elements. the most remarkable feature is the acquisition of two conjugative transposons and one resistance island encoding eight resistance genes. results of mlst suggested that the major driving force for the genome evolution is the environmental drug pressure. conclusion: the genome sequence of s. pneumoniae serotype 14 shows a bacterium with rapid adaptations to its lifecycle in human community. these include a versatile genome content, with a wide range of mobile elements, and chromosomal rearrangement; the latter re-balanced the genome after events of hgt.
WOS关键词	INVASIVE PNEUMOCOCCAL DISEASE ; MICROBIAL PAN-GENOME ; NUCLEOTIDE-SEQUENCE ; CONJUGATE VACCINE ; BINDING PROTEINS ; STRAIN R6 ; CHILDREN ; IDENTIFICATION ; GENES ; BIOSYNTHESIS
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
语种	英语
出版者	BIOMED CENTRAL LTD
WOS记录号	WOS:000266804600001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2401846
专题	中国科学院大学
通讯作者	Chiu, Cheng-Hsun
作者单位	1.Chang Gung Univ, Coll Med, Chang Gung Childrens Hosp, Dept Pediat, Tao Yuan, Taiwan 2.Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100029, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100029, Peoples R China 4.Chang Gung Univ, Coll Med, Dept Parasitol, Tao Yuan, Taiwan
推荐引用方式 GB/T 7714	Ding, Feng,Tang, Petrus,Hsu, Mei-Hua,et al. Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant streptococcus pneumoniae serotype 14[J]. Bmc genomics,2009,10:13.
APA	Ding, Feng.,Tang, Petrus.,Hsu, Mei-Hua.,Cui, Peng.,Hu, Songnian.,...&Chiu, Cheng-Hsun.(2009).Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant streptococcus pneumoniae serotype 14.Bmc genomics,10,13.
MLA	Ding, Feng,et al."Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant streptococcus pneumoniae serotype 14".Bmc genomics 10(2009):13.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。