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	The bone-derived collagen containing mineralized matrix for the loading of collagen-binding bone morphogenetic protein-2
	Zhao, Yannan1,2; Chen, Bing1; Lin, Hang1; Sun, Wenjie1; Zhao, Wenxue1; Zhang, Jing1; Dai, Jianwu1
刊名	Journal of biomedical materials research part a
	2009-03-01
卷号	88a期号:3页码:725-734
关键词	Ccmbm Bmp(2) Bone regeneration Ectopic bone formation
ISSN号	1549-3296
DOI	10.1002/jbm.a.31928
通讯作者	Dai, jianwu(jwdai@genetics.ac.cn)
英文摘要	Bone tissue-derived biomaterials have often been applied for bone repair because of their similarity to human bone in structure and composition. when combined with growth factors, they could accelerate bone formation. here, we explore a collagen containing mineralized bone-derived matrix (ccmbm) from bovine bone tissues, which not only maintains proper mechanical strength but also binds to the collagen-binding recombinant human collagen-binding bone morphogenetic protein-2 (cbd-bmp(2)). by analyzing its morphology and composition, we found that ccmbm was porous and mainly composed of calcium compounds. ccmbm could provide mechanical support for bone injury repair. it also showed good biocompatibility and proper degradation rate that would be helpful for bone regeneration. in addition, the intentionally preserved collagen allowed the specific binding of cbd-bmp2 to ccmbm, and resulted in significantly increased osteogenesis in vivo. the results indicated that the combination of ccmbm with collagen-binding bmp(2) could be emerged into an effective medical device for bone repair. (c) 2008 wiley periodicals, inc. j biomed mater res 88a: 725-734, 2009
WOS关键词	BETA-TRICALCIUM PHOSPHATE ; CONTROLLED-RELEASE ; CANCELLOUS BONE ; GROWTH-FACTORS ; 3-D SCAFFOLD ; IN-VITRO ; DEFECTS ; COMPOSITE ; CALCIUM ; SPONGE
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
语种	英语
出版者	WILEY-LISS
WOS记录号	WOS:000263126000020
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2398647
专题	中国科学院大学
通讯作者	Dai, Jianwu
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, Ctr Mol Dev Biol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Yannan,Chen, Bing,Lin, Hang,et al. The bone-derived collagen containing mineralized matrix for the loading of collagen-binding bone morphogenetic protein-2[J]. Journal of biomedical materials research part a,2009,88a(3):725-734.
APA	Zhao, Yannan.,Chen, Bing.,Lin, Hang.,Sun, Wenjie.,Zhao, Wenxue.,...&Dai, Jianwu.(2009).The bone-derived collagen containing mineralized matrix for the loading of collagen-binding bone morphogenetic protein-2.Journal of biomedical materials research part a,88a(3),725-734.
MLA	Zhao, Yannan,et al."The bone-derived collagen containing mineralized matrix for the loading of collagen-binding bone morphogenetic protein-2".Journal of biomedical materials research part a 88a.3(2009):725-734.

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