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	Effect of different regions of nogo-a on the differentiation of neural progenitors
	Gao, Yuan1,2; Xiao, Zhifeng1; Chen, Bing1; Wang, Bin1; Han, Jin1; Zhao, Yannan1; Zhang, Jing1; Dai, Jianwu1
刊名	Neuroscience letters
	2009-07-24
卷号	458期号:3页码:132-135
关键词	Nogo-a Functional region Neural progenitors Differentiation
ISSN号	0304-3940
DOI	10.1016/j.neulet.2009.04.034
通讯作者	Dai, jianwu(jwdai@genetics.ac.cn)
英文摘要	Nogo-a is an inhibitor of neurite outgrowth and axonal regeneration after cns injury. several functional regions including nogo-66 were identified to mediate the inhibitory effect of nogo-a. we have reported that nogo-66 could promote neural progenitors to differentiate into glial cells. here we exam three other regions of nogo-a and show two of them also mediate the differentiation of neural progenitors. a 172-residues n-terminal region and a 37-residues c-terminal region of nogo-a both could inhibit neuronal differentiation and promoted glial cell formation. this study illustrated that nogo-a had multiple functional domains on the behavior of neuronal cells. the inhibitory effect of neural differentiation of nogo-a may also contribute to its restraint of cns repair. (c) 2009 published by elsevier ireland ltd.
WOS关键词	NEURITE OUTGROWTH ; AXONAL REGENERATION ; NERVOUS-SYSTEM ; STEM-CELLS ; ADULT-RAT ; INHIBITOR ; EXPRESSION ; PATHWAY ; PROTEIN ; APOPTOSIS
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000266761200008
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2396639
专题	中国科学院大学
通讯作者	Dai, Jianwu
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Gao, Yuan,Xiao, Zhifeng,Chen, Bing,et al. Effect of different regions of nogo-a on the differentiation of neural progenitors[J]. Neuroscience letters,2009,458(3):132-135.
APA	Gao, Yuan.,Xiao, Zhifeng.,Chen, Bing.,Wang, Bin.,Han, Jin.,...&Dai, Jianwu.(2009).Effect of different regions of nogo-a on the differentiation of neural progenitors.Neuroscience letters,458(3),132-135.
MLA	Gao, Yuan,et al."Effect of different regions of nogo-a on the differentiation of neural progenitors".Neuroscience letters 458.3(2009):132-135.

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