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	The spatial relationship between heterochromatin protein 1 alpha and histone modifications during mouse oocyte meiosis
	Wang, Qiang1,2; Ai, Jun Shu1,2; Ola, Safiriyu Idowu1,3; Gu, Ling4; Zhang, Yong Zhong1; Chen, Da Yuan1; Sun, Qing Yuan1
刊名	Cell cycle
	2008-02-15
卷号	7期号:4页码:513-520
关键词	Hp1 Histone modification Epigenetics Mouse oocyte Meiosis
ISSN号	1538-4101
通讯作者	Sun, qing yuan(sunqy@ioz.ac.cn)
英文摘要	Heterochromatin protein 1 (hp1) is closely associated with diverse chromatin organization and function in mitosis. however, we almost know nothing about hp1 in mammalian oocyte. here, we investigated the subcellular distribution of hp1 alpha and its spatial relationship to histone modifications during mouse oocyte maturation. dynamic migration of hp1 alpha was observed in germinal vesicle with non-surrounded nucleolus (nsn) to surrounded nucleolus (sn) oocytes, which may be essential for the transition of chromatin conformation during the development of antral oocytes. in meiosis, hp1 alpha was clearly detectable at the periphery of chromosomes from pre-metaphase i stage to anaphase-telophase i stage. spatial correlation between hp1 alpha and histone modifications is highly variable around the time of meiotic resumption. in germinal vesicle oocytes, hp1 alpha almost colocalized with all histone modifications examined in this study except for phosphorylation of serine 28 on histone h3. however, with the breakdown of germinal vesicle, hp1 alpha was detected mostly in the chromosomal domains with strong phosphorylation of serine 10 and 28 on histone h3, and they also partially associated with methylated histones. these results presented the functional implication of histone modifications in the regulation of hp1 alpha during oocyte maturation. in addition, we also showed that blocking the function of hp1 alpha by microinjecting anti-hp1 alpha antibody caused the delay of gvbd, however, this effect may not be achieved through modifying histones.
WOS关键词	HETEROCHROMATIN PROTEIN-1 HP1 ; PERICENTRIC HETEROCHROMATIN ; MAMMALIAN-CELLS ; TRICHOSTATIN-A ; LYSINE 9 ; CHROMATIN ; H3 ; PHOSPHORYLATION ; METHYLATION ; BINDING
WOS研究方向	Cell Biology
WOS类目	Cell Biology
语种	英语
出版者	LANDES BIOSCIENCE
WOS记录号	WOS:000254364800016
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2393476
专题	中国科学院大学
通讯作者	Sun, Qing Yuan
作者单位	1.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China 3.Obafemi Awolowo Univ, Dept Anim Sci, Ife, Nigeria 4.China Agr Univ, Coll Biol Sci, Beijing 100094, Peoples R China
推荐引用方式 GB/T 7714	Wang, Qiang,Ai, Jun Shu,Ola, Safiriyu Idowu,et al. The spatial relationship between heterochromatin protein 1 alpha and histone modifications during mouse oocyte meiosis[J]. Cell cycle,2008,7(4):513-520.
APA	Wang, Qiang.,Ai, Jun Shu.,Ola, Safiriyu Idowu.,Gu, Ling.,Zhang, Yong Zhong.,...&Sun, Qing Yuan.(2008).The spatial relationship between heterochromatin protein 1 alpha and histone modifications during mouse oocyte meiosis.Cell cycle,7(4),513-520.
MLA	Wang, Qiang,et al."The spatial relationship between heterochromatin protein 1 alpha and histone modifications during mouse oocyte meiosis".Cell cycle 7.4(2008):513-520.

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