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	Genes of hippo signaling network act unconventionally in the control of germline proliferation in drosophila
	Sun, Shuguo1,2; Zhao, Shaowei1,2; Wang, Zhaohui1
刊名	Developmental dynamics
	2008
卷号	237期号:1页码:270-275
关键词	Hippo Expanded Germline Proliferation Drosophila
ISSN号	1058-8388
DOI	10.1002/dvdy.21411
通讯作者	Wang, zhaohui(zhwang@genetics.ac.cn)
英文摘要	Hippo pathway and its related genes are required for growth control in various somatic tissues. the mutations of hippo pathway components lead to tissue overgrowth cell-autonomously. surprisingly, when we generated germline mutant clones of hippo-network genes such as fat, expanded, hippo, salvador, and warts, we did not observe any overgrowth of these mutant cells. consistently, overexpression of the progrowth gene yorkie, which is normally inhibited by hippo signaling, did not lead to germline overgrowth either. in contrast to previous studies in epithelial tissues, these tumor suppressor genes are dispensable in germline cells for their proliferation control. furthermore, we demonstrate that expanded functions nonautonomously to regulate spermatogonial proliferation. it appears that expanded acts from the somatic support cells surrounding the germline to restrict spermatogonial amplification. developmental dynamics 237:270-275, 2008. (c) 2007 wiley-liss, inc.
WOS关键词	TUMOR-SUPPRESSOR PATHWAY ; REGULATE CELL-PROLIFERATION ; PROMOTES APOPTOSIS ; EXPANDED FUNCTION ; PROTEIN-KINASE ; CYCLE EXIT ; ORGAN SIZE ; FAT ; GROWTH ; SPERMATOGENESIS
WOS研究方向	Anatomy & Morphology ; Developmental Biology
WOS类目	Anatomy & Morphology ; Developmental Biology
语种	英语
出版者	WILEY-LISS
WOS记录号	WOS:000252386300026
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2386464
专题	中国科学院大学
通讯作者	Wang, Zhaohui
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol & Dev Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Sun, Shuguo,Zhao, Shaowei,Wang, Zhaohui. Genes of hippo signaling network act unconventionally in the control of germline proliferation in drosophila[J]. Developmental dynamics,2008,237(1):270-275.
APA	Sun, Shuguo,Zhao, Shaowei,&Wang, Zhaohui.(2008).Genes of hippo signaling network act unconventionally in the control of germline proliferation in drosophila.Developmental dynamics,237(1),270-275.
MLA	Sun, Shuguo,et al."Genes of hippo signaling network act unconventionally in the control of germline proliferation in drosophila".Developmental dynamics 237.1(2008):270-275.

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