Analytical strategies in lipidomics and applications in disease biomarker discovery

	Analytical strategies in lipidomics and applications in disease biomarker discovery
	Hu, Chunxiu 1,2; van der Heijden, Rob 2; Wang, Mei 3; van der Greef, Jan 2,3; Hankemeier, Thomas 2; Xua, Guowang 1
刊名	journal of chromatography b-analytical technologies in the biomedical and life sciences
	2009-09-15
卷号	877 期号:26 页码:2836-2846
关键词	Lipidomics Lipid-associated disorders Biomarkers Lipid profiling
通讯作者	许国旺
产权排序	1;1
英文摘要	lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. recently, lipid profiling, or so-called lipidomics research, has captured increased attention due to the well-recognized roles of lipids in numerous human diseases to which lipid-associated disorders contribute, such as diabetes, obesity, atherosclerosis and alzheimer's disease. investigating lipid biochemistry using a lipidomics approach will not only provide insights into the specific roles of lipid molecular species in health and disease, but will also assist in identifying potential biomarkers for establishing preventive or therapeutic approaches for human health. recent technological advancements in mass spectrometry and rapid improvements in chromatographic techniques have led to the rapid expansion of the lipidomics research held. in this review, emphasis is given to the recent advances in lipidomics technologies and their applications in disease biomarker discovery. (c) 2009 elsevier b.v. all rights reserved.
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	biochemical research methods ; chemistry, analytical
研究领域[WOS]	biochemistry & molecular biology ; chemistry
关键词[WOS]	performance liquid-chromatography ; ionization mass-spectrometry ; assisted laser-desorption ; multivariate statistical-analysis ; maldi-tof ms ; shotgun lipidomics ; cellular lipidomes ; biological samples ; lipoprotein metabolism ; phospholipid profiles
收录类别	SCI
原文出处	false
语种	英语
WOS记录号	WOS:000269224200017
公开日期	2010-11-30
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/102165]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Leiden Univ, Div Analyt Biosci, LACDR, NL-2300 RA Leiden, Netherlands 3.SU BioMed & TNO Qual Life, NL-3700 AJ Zeist, Netherlands
推荐引用方式 GB/T 7714	Hu, Chunxiu,van der Heijden, Rob,Wang, Mei,et al. Analytical strategies in lipidomics and applications in disease biomarker discovery[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2009,877(26):2836-2846.
APA	Hu, Chunxiu,van der Heijden, Rob,Wang, Mei,van der Greef, Jan,Hankemeier, Thomas,&Xua, Guowang.(2009).Analytical strategies in lipidomics and applications in disease biomarker discovery.journal of chromatography b-analytical technologies in the biomedical and life sciences,877(26),2836-2846.
MLA	Hu, Chunxiu,et al."Analytical strategies in lipidomics and applications in disease biomarker discovery".journal of chromatography b-analytical technologies in the biomedical and life sciences 877.26(2009):2836-2846.