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	Biodegradable poly(sebacic anhydride-co-caprolactone) multi-block copolymers: synthesis, characterization, crystallinity and crystalline morphology
	Miao, Hui; Fan, Ying; Liu, Yan; Liu, Yu; Hao, Jianyuan; Deng, Xianmo
刊名	European polymer journal
	2007-03-01
卷号	43期号:3页码:1055-1064
关键词	Biodegradable multi-block copolymers Poly(caprolactone-co-sebacic anhydride) Crystallinity Crystalline morphology Degradation properties
ISSN号	0014-3057
DOI	10.1016/j.eurpolymj.2006.12.013
通讯作者	Hao, jianyuan(j.hao@cioc.ac.cn)
英文摘要	Biodegradable poly(sebacic anhydride-co-caprolactone) (psa-co-pcl) multi-block copolymers were prepared by condensation of acylated psa and pcl prepolymers with different weight ratios. the homopolymer and copolymers were characterized by h-1-nmr, gel permeation chromatography (gpc), differential scanning calorimeter (dsc) and atom force microscope (afm). h-1-nmr and gpc has indicated the formation of psa-co-pcl multi-block copolymers, in which psa and pcl segments are randomly distributed. the incorporation of pcl segments into the molecule chains even at a content of 20 wt% could significantly decrease the molecular weight distribution of the copolymer and increase its weight average molecular weight, as compared with psa homopolymer. dsc has revealed that the melting temperature and degree of crystallinity for both sa and cl components are strongly composition dependent, implying the hindrance effect of the two components on crystallinity of each other. afm observation has shown the difference in crystalline structures between psa and pcl phases in the copolymers. in-vitro degradation tests performed at 37 degrees c in pbs buffer solution (ph 7.4, 0.1 m) have demonstrated the acceleration of degradation rate of the sample with increasing sa content in the copolymer. (c) 2007 elsevier ltd. all rights reserved.
WOS关键词	DRUG-CARRIER MATRICES ; BIOERODIBLE POLYANHYDRIDES ; MELTING BEHAVIOR ; BINARY BLENDS ; ACID ; DEGRADATION ; RELEASE ; POLYCAPROLACTONE ; MICROSPHERES ; MISCIBILITY
WOS研究方向	Polymer Science
WOS类目	Polymer Science
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000245064900040
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2383168
专题	中国科学院大学
通讯作者	Hao, Jianyuan
作者单位	1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 2.Polymer Res Inst, State Key Lab Polymer Mat & Engn, Chengdu 610065, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Miao, Hui,Fan, Ying,Liu, Yan,et al. Biodegradable poly(sebacic anhydride-co-caprolactone) multi-block copolymers: synthesis, characterization, crystallinity and crystalline morphology[J]. European polymer journal,2007,43(3):1055-1064.
APA	Miao, Hui,Fan, Ying,Liu, Yan,Liu, Yu,Hao, Jianyuan,&Deng, Xianmo.(2007).Biodegradable poly(sebacic anhydride-co-caprolactone) multi-block copolymers: synthesis, characterization, crystallinity and crystalline morphology.European polymer journal,43(3),1055-1064.
MLA	Miao, Hui,et al."Biodegradable poly(sebacic anhydride-co-caprolactone) multi-block copolymers: synthesis, characterization, crystallinity and crystalline morphology".European polymer journal 43.3(2007):1055-1064.

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