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	A proline iminopeptidase gene upregulated in planta by a luxr homologue is essential for pathogenicity of xanthomonas campestris pv. campestris
	Zhang, Lili; Jia, Yantao; Wang, Li; Fang, Rongxiang
刊名	Molecular microbiology
	2007-07-01
卷号	65期号:1页码:121-136
ISSN号	0950-382X
DOI	10.1111/j.1365-2958.2007.05775.x
通讯作者	Fang, rongxiang(fangrx@sun.im.ac.cn)
英文摘要	Expression of bacterial genes is often regulated by complex mechanisms, some of which involve host cues. analysis of the xanthomonas campestris pv. campestris (xcc) genome sequence revealed the presence of an xccr/pip locus. the upstream gene xccr is a luxr homologue, while pip codes for a proline iminopeptidase. a lux box-like element, named luxxc box, locates in the pip promoter region. in this work, we show that disruption of either xccr or pip resulted in significantly attenuated virulence of xcc. under medium culture conditions, the pip expression was significantly enhanced by overexpression of xccr and the luxxc box is necessary for this enhancement. we further show that expression of a pip promoter-gusa fusion either inserted in the bacterial chromosome or resided in a plasmid was markedly induced when the bacteria grew in planta. disruption of either xccr or the luxxc box abolished the in planta induction, while disruption of pip enhanced the induction. taken together, these data demonstrate that pip is indispensable for xcc virulence and suggest a model for xcc-host interaction in which the pathogen senses some host factor(s) to activate xccr that subsequently interacts with the luxxc box to induce the expression of pip for facilitating xcc infection.
WOS关键词	SENSING TRANSCRIPTION FACTOR ; PSEUDOMONAS-AERUGINOSA ; SIGNAL MOLECULES ; PROLYL AMINOPEPTIDASE ; BACILLUS-COAGULANS ; CELL COMMUNICATION ; VIBRIO-FISCHERI ; QUORUM ; EXPRESSION ; BACTERIA
WOS研究方向	Biochemistry & Molecular Biology ; Microbiology
WOS类目	Biochemistry & Molecular Biology ; Microbiology
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000247871600011
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2383153
专题	中国科学院大学
通讯作者	Fang, Rongxiang
作者单位	1.Chinese Acad Sci, Inst Microbiol, State Key Lab Plant Genom, Beijing 100101, Peoples R China 2.Natl Plant Gene Res Ctr, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Lili,Jia, Yantao,Wang, Li,et al. A proline iminopeptidase gene upregulated in planta by a luxr homologue is essential for pathogenicity of xanthomonas campestris pv. campestris[J]. Molecular microbiology,2007,65(1):121-136.
APA	Zhang, Lili,Jia, Yantao,Wang, Li,&Fang, Rongxiang.(2007).A proline iminopeptidase gene upregulated in planta by a luxr homologue is essential for pathogenicity of xanthomonas campestris pv. campestris.Molecular microbiology,65(1),121-136.
MLA	Zhang, Lili,et al."A proline iminopeptidase gene upregulated in planta by a luxr homologue is essential for pathogenicity of xanthomonas campestris pv. campestris".Molecular microbiology 65.1(2007):121-136.

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