QQ客服 官方微博 反馈留言

	A study of mechanisms involved in vasodilatation induced by resveratrol in isolated porcine coronary artery
	Li, H. -F.; Tian, Z. -F.; Qiu, X. -Q.; Wu, J. -X.; Zhang, P.; Jia, Z. -J.
刊名	Physiological research
	2006
卷号	55期号:4页码:365-372
关键词	Resveratrol Coronary artery Calcium channel Vascular endothelium Nitric oxide
ISSN号	0862-8408
通讯作者	Jia, z. -j.()
英文摘要	The present study was designed to investigate the acute relaxing effect of phytoestrogen resveratrol on isolated porcine coronary arteries and to determine the mechanisms underlying its vasodilatation. rings of porcine coronary arteries were suspended in organ baths containing krebs-henseleit solution, and then isometric tension was measured. resveratrol concentration-dependently relaxed arterial rings precontracted with 30 mm kcl. the ic50 value of resveratrol was 38.67 +/- 3.21 mu m. incubation with n-infinity-l-nitro-arginine (l-nna), endothelium removal or the presence of a potent inhibitor of protein tyrosine phosphatase sodium orthovanadate partly decreased the relaxation induced by resveratrol. however, the relaxation induced by resveratrol was unaffected by the estrogen receptor antagonist tamoxifen, the inhibitor of prostanoid synthesis indomethacin, the antagonist of beta-adrenoceptors propranolol or the protein synthesis inhibitor, cycloheximide. in addition, resveratrol significantly decreased the contractile responses of 5-ht, kcl and cacl2, and shifted their cumulative concentration-response curves to the right. these results suggest that the mechanisms of vasorelaxation induced by resveratrol are heterogeneous, two mechanisms participating partially in the relaxation of porcine coronary artery were detected in the study, one being the nitric oxide released from the endothelium, the other causing inhibition of ca2+ influx, but estrogen receptors were not involved in resveratrol-induced relaxation.
WOS关键词	ISCHEMIA-REPERFUSION INJURY ; TYROSINE KINASE ; TRANS-RESVERATROL ; SMOOTH-MUSCLE ; NITRIC-OXIDE ; RED WINE ; PHOSPHORYLATION ; VASORELAXATION ; ESTROGENS ; RESPONSES
WOS研究方向	Physiology
WOS类目	Physiology
语种	英语
出版者	ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
WOS记录号	WOS:000240124800002
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2379952
专题	中国科学院大学
通讯作者	Jia, Z. -J.
作者单位	1.Lanzhou Univ, Coll Chem & Chem Engn, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu Province, Peoples R China 2.Lanzhou Univ, Funct Lab Med, Lanzhou 730000, Peoples R China 3.Lanzhou Univ, Coll Basic Med, Dept Physiol, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Li, H. -F.,Tian, Z. -F.,Qiu, X. -Q.,et al. A study of mechanisms involved in vasodilatation induced by resveratrol in isolated porcine coronary artery[J]. Physiological research,2006,55(4):365-372.
APA	Li, H. -F.,Tian, Z. -F.,Qiu, X. -Q.,Wu, J. -X.,Zhang, P.,&Jia, Z. -J..(2006).A study of mechanisms involved in vasodilatation induced by resveratrol in isolated porcine coronary artery.Physiological research,55(4),365-372.
MLA	Li, H. -F.,et al."A study of mechanisms involved in vasodilatation induced by resveratrol in isolated porcine coronary artery".Physiological research 55.4(2006):365-372.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。