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	Paradoxical effects of very low dose mk-801
	Tang, YJ; Zou, H; Strong, JA; Cui, YW; Xie, QP; Zhao, GP; Jin, ML; Yu, L
刊名	European journal of pharmacology
	2006-05-10
卷号	537期号:1-3页码:77-84
关键词	Dizocilpine maleate Nmda receptor antagonist Locomotion Immobility Catalepsy Haloperidol
ISSN号	0014-2999
DOI	10.1016/j.ejphar.2006.03.016
通讯作者	Jin, ml()
英文摘要	Systemic injection of the noncompetitive nmda (n-methyl-d-aspartate) receptor antagonist mk-801 (dizocilpine maleate) is known to cause increased locomotion and various stereotypic behaviors in rodents. however, the mk-801 dose ranges commonly examined usually begin at tenth of mg/kg and going higher, with the implicit assumption of lower doses being ineffective. we report here that very low dose mk-801, well below the commonly studied doses, exert distinct effects on rodent behaviors. in c57bl/6 mice, very low dose mk-801 (0.02 mg/kg) has strikingly different effects than higher doses commonly reported in the literature. locomotion, rearing, grooming, and other behaviors are strongly inhibited, replaced by periods of immobility. this is in contrast to the mobility-enhancing effect of mk-801 at commonly reported dose ranges. the effects of very low dose mk-801 are qualitatively similar to those observed with moderate doses (0.1-0.2 mg/kg) of the typical antipsychotic, haloperidol. these results highlight the complexity of the dose-response relation for mk-801-induced behaviors. (c) 2006 published by elsevier b.v.
WOS关键词	METHYL-D-ASPARTATE ; RECEPTOR SUBTYPES ; BASAL GANGLIA ; SCHIZOPHRENIA ; GLUTAMATE ; MICE ; PHARMACOLOGY ; INVOLVEMENT ; STEREOTYPY ; CATALEPSY
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000237889000012
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2379397
专题	中国科学院大学
通讯作者	Jin, ML
作者单位	1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Res Ctr Biotechnol, Shanghai 200233, Peoples R China 2.Univ Cincinnati, Coll Med, Dept Cell Biol Neurobiol & Anat, Cincinnati, OH 45267 USA 3.Rutgers State Univ, Dept Genet, Piscataway, NJ 08854 USA 4.Rutgers State Univ, Ctr Alcohol Studies, Piscataway, NJ 08854 USA
推荐引用方式 GB/T 7714	Tang, YJ,Zou, H,Strong, JA,et al. Paradoxical effects of very low dose mk-801[J]. European journal of pharmacology,2006,537(1-3):77-84.
APA	Tang, YJ.,Zou, H.,Strong, JA.,Cui, YW.,Xie, QP.,...&Yu, L.(2006).Paradoxical effects of very low dose mk-801.European journal of pharmacology,537(1-3),77-84.
MLA	Tang, YJ,et al."Paradoxical effects of very low dose mk-801".European journal of pharmacology 537.1-3(2006):77-84.

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