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	Porous akermanite scaffolds for bone tissue engineering: preparation, characterization, and in vitro studies
	Wu, CT; Chang, JA; Zhai, WY; Ni, SY; Wang, JY
刊名	Journal of biomedical materials research part b-applied biomaterials
	2006-07-01
卷号	78b期号:1页码:47-55
关键词	Akermanite scaffolds Bioactive Degradable Alp Cytocompatible
ISSN号	1552-4973
DOI	10.1002/jbm.b.30456
通讯作者	Chang, ja()
英文摘要	The aim of this study was to develop a bioactive, degradable, and cytocompatible akermanite (ca2mgsi2o7) scaffold with high porosity and pore interconnectivity. in brief, porous akermanite scaffolds were prepared using polymer sponge method. the porosity and corresponding compressive strength were evaluated. the in vitro degradability was investigated by soaking the scaffolds in ringer's solution. hydroxyapatite (hap)-formation ability of akermantite scaffolds in simulated body fluid (sbf) and the effect of ionic products from the scaffolds dissolution on osteoblasts were investigated. in addition, bone marrow stromal cells (bmsc) adhesion and proliferation on the scaffolds were evaluated. differentiation of the cells was assessed by measuring alkaline phosphatase (alp) activity. the results showed that akermanite scaffolds possessed 63.5-90.3% of porosity, with a corresponding compressive strength between 1130 and 530 kpa. the weight loss of the scaffolds and ionic content of the ringer's solution increased with the increase in soaking time, indicating the degradability of scaffolds. hap was formed on the scaffolds in sbf and the ionic products from akermanite scaffolds dissolution stimulated osteoblasts proliferation, indicating good in vitro bioactivity. furthermore, bmsc adhered and spread well on akermanite scaffolds and proliferated with the increase in the culture time, and the differentiation rate of osteoblasts on scaffolds was comparable to that on blank culture plate control. our results suggested that akermanite scaffolds were bioactive, degradable, and cytocompatible, and might be used as bone tissue lengineering materials. (c) 2005 wiley periodicals, inc.
WOS关键词	BIOACTIVE GLASS ; IONIC PRODUCTS ; APATITE LAYER ; HYDROXYAPATITE ; BIOMATERIALS ; CERAMICS ; PROLIFERATION ; DISSOLUTION ; DIOPSIDE ; ADHESION
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
语种	英语
出版者	WILEY-LISS
WOS记录号	WOS:000238737300007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2379044
专题	中国科学院大学
通讯作者	Chang, JA
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, Biomat & Tissue Engn Res Ctr, Shanghai 200050, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.E China Normal Univ, Sch Biol Sci, Shanghai 200062, Peoples R China
推荐引用方式 GB/T 7714	Wu, CT,Chang, JA,Zhai, WY,et al. Porous akermanite scaffolds for bone tissue engineering: preparation, characterization, and in vitro studies[J]. Journal of biomedical materials research part b-applied biomaterials,2006,78b(1):47-55.
APA	Wu, CT,Chang, JA,Zhai, WY,Ni, SY,&Wang, JY.(2006).Porous akermanite scaffolds for bone tissue engineering: preparation, characterization, and in vitro studies.Journal of biomedical materials research part b-applied biomaterials,78b(1),47-55.
MLA	Wu, CT,et al."Porous akermanite scaffolds for bone tissue engineering: preparation, characterization, and in vitro studies".Journal of biomedical materials research part b-applied biomaterials 78b.1(2006):47-55.

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