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	Glutathione-s-transferase m1 polymorphisms on the susceptibility to esophageal cancer among three chinese minorities: kazakh, tajik and uygur
	Lu, Xiao-Mei; Yang, Ting; Xu, Shu-Yong; Wen, Hao; Wang, Xing; Ren, Zhi-Hui; Zhang, Yan; Wang, Wei
刊名	World journal of gastroenterology
	2006-12-28
卷号	12期号:48页码:7758-7761
关键词	Glutathione-s-transferase m1 Kazakh Uygur Tajik Esophageal cancer
ISSN号	1007-9327
通讯作者	Wang, wei()
英文摘要	Aim: to investigate the glutathione-s-transferase m1 (gstm1) polymorphisms in three chinese minorities, kazakh, uygur, and tajik; and the pathological significance of gstm1 polymorphisms in esophageal carcinogenesis in kazakh. methods: a total of 1121 blood samples (442 males and 679 females) were obtained from healthy kazakh (654), uygur (412) and tajik (55). primary esophageal squamous cell cancer (escc) tissues from kazakh were obtained from 116 patients who underwent surgery. gstm1 polymorphisms were analyzed by a combined approach of pcr and electrophoresis techniques. results: gstm1 null genotype was found in 62.63% uygur, 50.91% tajik and 47.40% kazakh. a significantly higher frequency of gstm1 null genotype in uygur was observed compared with kazakh (or: 1.859, 95% ci: 1.445 -2.391, chi(2) = 23.71, p = 0.000). in addition, gstm1 null genotype was found in 23.53% of well-differentiated escc in kazakh, in 49.23% of poorly differentiated escc, with a significant difference (or: 3.152, 95% ci: 1.403-7.080, chi(2) = 8.018, p = 0.007). conclusion: there is a marked difference in the frequency of common gstm1 null genotype between uygur and kazakh. gstm1 null genotype is associated with differentiation of escc in kazakh. (c) 2006 the wjg press. all rights reserved.
WOS关键词	GENETIC POLYMORPHISMS ; BLADDER-CANCER ; NULL GENOTYPE ; GSTT1 POLYMORPHISMS ; INCREASED RISK ; GSTM1 ; METAANALYSIS ; ASSOCIATION ; GSTP1 ; T1
WOS研究方向	Gastroenterology & Hepatology
WOS类目	Gastroenterology & Hepatology
语种	英语
出版者	W J G PRESS
WOS记录号	WOS:000243309900005
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2378998
专题	中国科学院大学
通讯作者	Wang, Wei
作者单位	1.Chinese Acad Sci, Grad Sch, Dept Biol, Beijing 100049, Peoples R China 2.Xinjiang Med Univ, Teaching Hosp 1, Med Res Ctr, Urumqi 830054, Xinjiang, Peoples R China 3.Xinjiang Med Univ, Basic Med Coll, Urumqi 830054, Xinjiang Uygur, Peoples R China
推荐引用方式 GB/T 7714	Lu, Xiao-Mei,Yang, Ting,Xu, Shu-Yong,et al. Glutathione-s-transferase m1 polymorphisms on the susceptibility to esophageal cancer among three chinese minorities: kazakh, tajik and uygur[J]. World journal of gastroenterology,2006,12(48):7758-7761.
APA	Lu, Xiao-Mei.,Yang, Ting.,Xu, Shu-Yong.,Wen, Hao.,Wang, Xing.,...&Wang, Wei.(2006).Glutathione-s-transferase m1 polymorphisms on the susceptibility to esophageal cancer among three chinese minorities: kazakh, tajik and uygur.World journal of gastroenterology,12(48),7758-7761.
MLA	Lu, Xiao-Mei,et al."Glutathione-s-transferase m1 polymorphisms on the susceptibility to esophageal cancer among three chinese minorities: kazakh, tajik and uygur".World journal of gastroenterology 12.48(2006):7758-7761.

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