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	Synthesis and biological evaluation of (+/-)-cryptotanshinone and its simplified analogues as potent cdc25 inhibitors
	Huang, WG; Jiang, YY; Li, Q; Li, J; Li, JY; Lu, W; Cai, JC
刊名	Tetrahedron
	2005-02-14
卷号	61期号:7页码:1863-1870
关键词	Cdc25 inhibitor Cryptotanshinone Analogues Antitumor
ISSN号	0040-4020
DOI	10.1016/j.tet.2004.12.033
通讯作者	Li, j()
英文摘要	(+/-)-cryptotanshinone and its simplified analogues were synthesized via smi2 promoted radical cyclization to construct the furan ring. analogues 18 and 26 were identified as effective inhibitors of dual specificity protein phosphatase cdc25b which is a key enzyme for cell cycle progression, and they also inhibited growth in a-549 human lung cancer cell line. (c) 2004 elsevier ltd. all rights reserved.
WOS关键词	SPECIFICITY PHOSPHATASE INHIBITORS ; HUMAN COLORECTAL-CARCINOMA ; CELL-CYCLE ARREST ; PROTEIN PHOSPHATASE ; SALVIA-MILTIORRHIZA ; TANSHINONE-IIA ; TYROSINE ; DYSIDIOLIDE ; QUINONES ; CRYPTOTANSHINONE
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000226915200025
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2377399
专题	中国科学院大学
通讯作者	Li, J
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, SIBS, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Huang, WG,Jiang, YY,Li, Q,et al. Synthesis and biological evaluation of (+/-)-cryptotanshinone and its simplified analogues as potent cdc25 inhibitors[J]. Tetrahedron,2005,61(7):1863-1870.
APA	Huang, WG.,Jiang, YY.,Li, Q.,Li, J.,Li, JY.,...&Cai, JC.(2005).Synthesis and biological evaluation of (+/-)-cryptotanshinone and its simplified analogues as potent cdc25 inhibitors.Tetrahedron,61(7),1863-1870.
MLA	Huang, WG,et al."Synthesis and biological evaluation of (+/-)-cryptotanshinone and its simplified analogues as potent cdc25 inhibitors".Tetrahedron 61.7(2005):1863-1870.

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