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	Inhibitory effect of ganglioside gd1b on k+ current in hippocampal neurons and its involvement in apoptosis suppression
	Chen, XS; Chi, SP; Liu, MN; Yang, W; Wei, TT; Qi, Z; Yang, FY
刊名	Journal of lipid research
	2005-12-01
卷号	46期号:12页码:2580-2585
关键词	Ion channel regulation Potassium channel Sphingolipids Lipid rafts/microdomains
ISSN号	0022-2275
DOI	10.1194/jlr.m500252-jlr200
通讯作者	Qi, z()
英文摘要	Gangliosides are endogenous membrane components enriched in neuronal cells. they have been shown to play regulatory roles in many cellular processes. here, we show for the first time that ganglioside gd1b plays an antiapoptotic role in cultured hippocampal neurons. gd1b inhibited the voltage- dependent outward delayed rectifier current ( i-k) but not the transient outward a- type current in a dose- dependent manner, with an ic50 value of 15.2 mu m. this effect appears to be somehow specific, because gd1b, but not gm1, gm2, gm3, gd1a, gd3, or gt1b, was effective in inhibiting i k. intracellular application of staurosporine ( sts; 0.1 mu m) resulted in rapid activation of i k, which was partially reversed upon addition of the k (+) channel blocker tetraethylammonium ( tea; 5 mm) and gd1b ( 10 mu m). furthermore, gd1b ( 10 mu m) attenuated sts- induced neuronal apoptosis by nearly the same amount as 5 mm tea. in addition, gd1b suppressed the apoptosis- associated caspase 3 activation that was activated by sts. collectively, these findings suggest that gd1b plays an antiapoptotic role in cultured hippocampal neurons through its inhibitory effect on the i k and caspase activity. - chen, x., s. chi, m. liu, w. yang, t. wei, z. qi, and f. yang. inhibitory effect of ganglioside gd1b on k (+) current in hippocampal neurons and its involvement in apoptosis suppression.
WOS关键词	OUTWARD POTASSIUM CURRENT ; PROGRAMMED CELL-DEATH ; LIPID RAFTS ; PLASMA-MEMBRANE ; COMPLEX GANGLIOSIDES ; NERVOUS-SYSTEM ; CHANNELS ; DIFFERENTIATION ; ACTIVATION ; ENHANCEMENT
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
语种	英语
出版者	AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
WOS记录号	WOS:000233301100005
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2377240
专题	中国科学院大学
通讯作者	Qi, Z
作者单位	1.Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Natl Lab Biomacromol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Chen, XS,Chi, SP,Liu, MN,et al. Inhibitory effect of ganglioside gd1b on k+ current in hippocampal neurons and its involvement in apoptosis suppression[J]. Journal of lipid research,2005,46(12):2580-2585.
APA	Chen, XS.,Chi, SP.,Liu, MN.,Yang, W.,Wei, TT.,...&Yang, FY.(2005).Inhibitory effect of ganglioside gd1b on k+ current in hippocampal neurons and its involvement in apoptosis suppression.Journal of lipid research,46(12),2580-2585.
MLA	Chen, XS,et al."Inhibitory effect of ganglioside gd1b on k+ current in hippocampal neurons and its involvement in apoptosis suppression".Journal of lipid research 46.12(2005):2580-2585.

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