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	Sarcomeres pattern proprioceptive sensory dendritic endings through unc-52/perlecan in c. elegans
	Liang, Xing1,2; Dong, Xintong3; Moerman, Donald G.4; Shen, Kang1,3; Wang, Xiangming1
刊名	Developmental cell
	2015-05-26
卷号	33期号:4页码:388-400
ISSN号	1534-5807
DOI	10.1016/j.devcel.2015.03.010
通讯作者	Shen, kang(kangshen@stanford.edu)
英文摘要	Sensory dendrites innervate peripheral tissues through cell-cell interactions that are poorly understood. the proprioceptive neuron pvd in c. elegans extends regular terminal dendritic branches between muscle and hypodermis. we found that the pvd branch pattern was instructed by adhesion molecule sax-7/l1cam, which formed regularly spaced stripes on the hypodermal cell. the regularity of the sax-7 pattern originated from the repeated and regularly spaced dense body of the sarcomeres in the muscle. the extracellular proteoglycan unc-52/perlecan linked the dense body to the hemidesmosome on the hypodermal cells, which in turn instructed the sax-7 stripes and pvd dendrites. both unc-52 and hemidesmosome components exhibited highly regular stripes that interdigitated with the sax-7 stripe and pvd dendrites, reflecting the striking precision of subcellular patterning between muscle, hypodermis, and dendrites. hence, the muscular contractile apparatus provides the instructive cues to pattern proprioceptive dendrites.
WOS关键词	CAENORHABDITIS-ELEGANS ; COMPLEX PATTERNS ; UNC-52 GENE ; DROSOPHILA ; ADHESION ; MECHANISMS ; NEURONS ; MECHANOTRANSDUCTION ; MORPHOGENESIS ; ARBORIZATION
WOS研究方向	Cell Biology ; Developmental Biology
WOS类目	Cell Biology ; Developmental Biology
语种	英语
出版者	CELL PRESS
WOS记录号	WOS:000355151900005
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376523
专题	中国科学院大学
通讯作者	Shen, Kang
作者单位	1.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100101, Peoples R China 3.Stanford Univ, Howard Hughes Med Inst, Dept Biol, Stanford, CA 94305 USA 4.Univ British Columbia, Dept Zool, Vancouver, BC V6T 1Z3, Canada
推荐引用方式 GB/T 7714	Liang, Xing,Dong, Xintong,Moerman, Donald G.,et al. Sarcomeres pattern proprioceptive sensory dendritic endings through unc-52/perlecan in c. elegans[J]. Developmental cell,2015,33(4):388-400.
APA	Liang, Xing,Dong, Xintong,Moerman, Donald G.,Shen, Kang,&Wang, Xiangming.(2015).Sarcomeres pattern proprioceptive sensory dendritic endings through unc-52/perlecan in c. elegans.Developmental cell,33(4),388-400.
MLA	Liang, Xing,et al."Sarcomeres pattern proprioceptive sensory dendritic endings through unc-52/perlecan in c. elegans".Developmental cell 33.4(2015):388-400.

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