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	Low molecular weight fucoidan modulates p-selectin and alleviates diabetic nephropathy
	Xu, Yingjie1,2,3; Zhang, Quanbin1,2,5; Luo, Dali4; Wang, Jing1,2; Duan, Delin1,2,5
刊名	International journal of biological macromolecules
	2016-10-01
卷号	91页码:233-240
关键词	Fucoidan Diabetic nephropathy P-selectin
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2016.05.081
通讯作者	Zhang, quanbin(qbzhang@qdio.ac.cn) ; Duan, delin(dlduan@qdio.ac.cn)
英文摘要	Diabetic nephropathy (dn) is a serious microvascular complication that can lead to chronic and end stage renal failure. it is understood that inflammation is associated with the onset and process of dn. low molecular weight fucoidan (lmwf) isolated from saccharina japonica has anti-inflammatory properties. therefore, this study aimed to explore the mechanism of lmwf in dn model induced by streptozotocin. the biochemical indices levels showed lmwf reduced the dn diagnostic indices to protect renal function. the he stained sections exhibited lmwf protected normal morphological structures and reduced inflammatory cell infiltration in the kidneys of dn rats. furthermore, the levels of p-selectin and selectin-dependent inflammatory cytokines resulting from lmwf were obviously decreased at both the transcriptional and protein levels. thus, our results found that lmwf protected the renal function in dn rats and alleviated inflammation through the modulation of p-selectin and inflammatory cytokines. lmwf may have therapeutic potential against dn. (c) 2016 elsevier b.v. all rights reserved.
WOS关键词	LAMINARIA-JAPONICA ; TGF-BETA ; PATHOGENETIC MECHANISMS ; SACCHARINA-JAPONICA ; GENE-EXPRESSION ; TNF-ALPHA ; CELLS ; ADHESION ; INJURY ; INFLAMMATION
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000382339200028
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376323
专题	中国科学院大学
通讯作者	Zhang, Quanbin; Duan, Delin
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Dept Pharmacol, Beijing 100069, Peoples R China 5.State Key Lab Seaweed Bioact Subst, Qingdao 266000, Peoples R China
推荐引用方式 GB/T 7714	Xu, Yingjie,Zhang, Quanbin,Luo, Dali,et al. Low molecular weight fucoidan modulates p-selectin and alleviates diabetic nephropathy[J]. International journal of biological macromolecules,2016,91:233-240.
APA	Xu, Yingjie,Zhang, Quanbin,Luo, Dali,Wang, Jing,&Duan, Delin.(2016).Low molecular weight fucoidan modulates p-selectin and alleviates diabetic nephropathy.International journal of biological macromolecules,91,233-240.
MLA	Xu, Yingjie,et al."Low molecular weight fucoidan modulates p-selectin and alleviates diabetic nephropathy".International journal of biological macromolecules 91(2016):233-240.

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