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	A beta-lactamase-imprinted responsive hydrogel for the treatment of antibiotic-resistant bacteria
	Li, Wen1,2,3; Dong, Kai1,2,3; Ren, Jinsong1,2; Qu, Xiaogang1,2
刊名	Angewandte chemie-international edition
	2016-07-04
卷号	55期号:28页码:8049-8053
关键词	Antibiotics Antibiotic resistance Enzymes Molecular imprinting Responsive hydrogels
ISSN号	1433-7851
DOI	10.1002/anie.201600205
通讯作者	Qu, xiaogang(xqu@ciac.ac.cn)
英文摘要	Antibiotics play important roles in infection treatment and prevention. however, the effectiveness of antibiotics is now threatened by the prevalence of drug-resistant bacteria. furthermore, antibiotic abuse and residues in the environment cause serious health issues. in this study, a stimuli-responsive imprinted hydrogel was fabricated by using beta-lactamase produced by bacteria for deactivating antibiotics as the template molecule. the imprinted hydrogel could initially trap beta-lactamase excreted by drug-resistant bacteria, thus making bacteria sensitive to antibiotics. after the bactericidal treatment, the "imprinted sites" on the hydrogel could be reversibly abolished with a temperature stimulus, which resulted in the reactivation of beta-lactamase to degrade antibiotic residues. we also present an example of the use of this antibacterial design to treat wound infection.
WOS关键词	POLYMER NANOPARTICLES ; BORONATE AFFINITY ; CANCER-CELLS ; INHIBITORS ; NANOSENSOR ; PARTICLES ; DESIGN ; MILK
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000383253100029
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376279
专题	中国科学院大学
通讯作者	Qu, Xiaogang
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Li, Wen,Dong, Kai,Ren, Jinsong,et al. A beta-lactamase-imprinted responsive hydrogel for the treatment of antibiotic-resistant bacteria[J]. Angewandte chemie-international edition,2016,55(28):8049-8053.
APA	Li, Wen,Dong, Kai,Ren, Jinsong,&Qu, Xiaogang.(2016).A beta-lactamase-imprinted responsive hydrogel for the treatment of antibiotic-resistant bacteria.Angewandte chemie-international edition,55(28),8049-8053.
MLA	Li, Wen,et al."A beta-lactamase-imprinted responsive hydrogel for the treatment of antibiotic-resistant bacteria".Angewandte chemie-international edition 55.28(2016):8049-8053.

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