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	Synthesis of ph-sensitive self-assembled amphiphilic graft copolymers containing 4,4,4,3,3,2-hexafluorobutyl side chains
	Tan, Jianquan1,2,3; Liu, Weiqu1,2; Wang, Zhengfang1,2
刊名	Journal of fluorine chemistry
	2016-09-01
卷号	189页码:79-87
关键词	Ph-sensitive Amphiphilic graft copolymer Self-assembled 4,4,4,3,3,2-hexafluorobutyl side chains Cytotoxicity
ISSN号	0022-1139
DOI	10.1016/j.jfluchem.2016.08.001
通讯作者	Liu, weiqu(liuwq@gic.ac.cn)
英文摘要	Novel amphiphilic graft copolymers containing 4,4,4,3,3,2-hexafluorobutyl side chains were designed and synthesized via radical polymerizaion of acrylic acid (aa), poly (ethylene glycol) methyl ether methacrylate (pegma) and homemade fluorinated macromonomer (phfbma-gma) and the physicochemical properties of polymeric micelles prepared therefrom were investigated. gpc, ftir and h-1 nmr were employed to characterize the structures of the copolymers. potentiometric titration measurement confirmed that the ph-sensitive segments were successfully incorporated and the copolymer performed pka similar to the reported values. a series of random copolymers with the same chemical composition were employed to make comparisons with the graft copolymers. the critical micelle concentrations (cmc) of the copolymers at different ph (5.0 and 9.0) were determined by fluorescence spectroscopy and surface tension measurements. cmc values showed a high degree of consistency between these two methods. the results showed that cmc values for random copolymers were one magnitude order higher than that of graft copolymers. graft copolymers performed lower cmc larger particle size compared to random copolymers. no significant difference was observed among graft or random copolymers. cmc values and particle size increased while zeta potential values showed significant decrement with increasing ph, indicating significant ph-sensitivity of the copolymers. with regard to the influence of the amount and the molecular weight of phfbma-gma on the properties, increasing the amount and molecular weight of phfbma-gma was prone to lower cmc, larger particle size while zeta potential performed no significant change. transmission electron microscopy (tem) showed that the morphological shapes of the copolymers performed spherical micelles. the cytotoxicity test showed that the comb-shaped copolymers performed extremely low cytotoxicity. the ph-sensitive self assembled amphiphilic graft copolymers containing 4,4,4,3,3,2-hexafluorobutyl side chains could be potential candidates for nanotanks, hydrophobic drug carriers or surfactants and their facile preparation might fit for large scale industrialization. (c) 2016 elsevier b.v. all rights reserved.
WOS关键词	LOW SURFACE-ENERGY ; HYDROPHOBIC BACKBONE ; HYDROPHILIC BRANCHES ; METHACRYLATE)-G-POLY(METHYL METHACRYLATE) ; MICELLES ; POLYMERIZATION ; OLIGOVINYLPYRROLIDONE ; MACROMONOMER ; DELIVERY ; BEHAVIOR
WOS研究方向	Chemistry
WOS类目	Chemistry, Inorganic & Nuclear ; Chemistry, Organic
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000383010300012
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376226
专题	中国科学院大学
通讯作者	Liu, Weiqu
作者单位	1.Chinese Acad Sci, Guangzhou Inst Chem, Guangzhou 510650, Guangdong, Peoples R China 2.Chinese Acad Sci, Key Lab Cellulose & Lignocellulos Chem, Guangzhou 510650, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Tan, Jianquan,Liu, Weiqu,Wang, Zhengfang. Synthesis of ph-sensitive self-assembled amphiphilic graft copolymers containing 4,4,4,3,3,2-hexafluorobutyl side chains[J]. Journal of fluorine chemistry,2016,189:79-87.
APA	Tan, Jianquan,Liu, Weiqu,&Wang, Zhengfang.(2016).Synthesis of ph-sensitive self-assembled amphiphilic graft copolymers containing 4,4,4,3,3,2-hexafluorobutyl side chains.Journal of fluorine chemistry,189,79-87.
MLA	Tan, Jianquan,et al."Synthesis of ph-sensitive self-assembled amphiphilic graft copolymers containing 4,4,4,3,3,2-hexafluorobutyl side chains".Journal of fluorine chemistry 189(2016):79-87.

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