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	Comparison of some antineoplastic drugs on inhibiting thrombin catalizing fibrinogen clotting in vitro
	Lu, DY; Cao, JY; Huang, YP; Gong, L; Chen, XL; Chen, EH; Xu, B
刊名	Chinese medical journal
	1999-11-01
卷号	112期号:11页码:1052-1053
关键词	Fibrin Fibrinogen Antineoplastic drugs Neoplasm metastasis
ISSN号	0366-6999
通讯作者	Lu, dy()
英文摘要	Objective to classify the effect of thrombin, the key enzyme which enables fibrinogen to form fibrin (fibrinogen clotting) on the formation of metastasis by comparing the inhibition of some antineoplastic drugs on fibrinogen clotting in vitro. methods time intervals of different drugs to reach a maximum od (340 nm) data in fibrinogen solution added with thrombin were used in this work. results it was found that l-4-oxalysine (8-40 mu g/ml) and arabinosyl cytosine (10-50 mu g/ml) could inhibit the effect of thrombin by extending the fibrinogen clotting time to 100% - 150% (p< 0.001) and 61% -100% (p < 0.001) while the other antimetastatic drugs razoxane, probimane, adriamycin, harringtonine homoharringtonine and alpha-anordrin at the treatment concentrations showed no such activity. the positive rate of drugs to thrombin activity was approximately 25%. conclusion it suggests that l-4-oxalysine and arabinosyl cytosine may even exhibit antimetastatic effect through thrombin-fibrinogen pathway, and thrombin might operate in tumor metastasis for only limited step but crutial to fibrin formation in tumor nodules.
WOS关键词	TUMOR ; COAGULATION
WOS研究方向	General & Internal Medicine
WOS类目	Medicine, General & Internal
语种	英语
出版者	CHINESE MEDICAL ASSOCIATION
WOS记录号	WOS:000083863800033
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376050
专题	武汉病毒研究所
通讯作者	Lu, DY
作者单位	1.Shanghai Univ, Sch Life Sci, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China 3.Cent Hosp Jing An Dist, Dept Oncol, Shanghai 200040, Peoples R China
推荐引用方式 GB/T 7714	Lu, DY,Cao, JY,Huang, YP,et al. Comparison of some antineoplastic drugs on inhibiting thrombin catalizing fibrinogen clotting in vitro[J]. Chinese medical journal,1999,112(11):1052-1053.
APA	Lu, DY.,Cao, JY.,Huang, YP.,Gong, L.,Chen, XL.,...&Xu, B.(1999).Comparison of some antineoplastic drugs on inhibiting thrombin catalizing fibrinogen clotting in vitro.Chinese medical journal,112(11),1052-1053.
MLA	Lu, DY,et al."Comparison of some antineoplastic drugs on inhibiting thrombin catalizing fibrinogen clotting in vitro".Chinese medical journal 112.11(1999):1052-1053.

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