| Sensitizing nanoparticle based platinum(iv) drugs by curcumin for better chemotherapy | |
| Kang, Xiang1; Zhao, Chen2; Yan, Lesan3,4; Qi, Ruogu3,4; Jing, Xiabin3; Wang, Zehua1 | |
| 刊名 | Colloids and surfaces b-biointerfaces
 |
| 2016-09-01 | |
| 卷号 | 145页码:812-819 |
| 关键词 | Cisplatin Curcumin Combination therapy Drug delivery Drug resistance |
| ISSN号 | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2016.05.084 |
| 通讯作者 | Yan, lesan(lesanyan@gmail.com) ; Qi, ruogu(ruoguqix@gmail.com) |
| 英文摘要 | A polymer-cisplatin(iv) conjugate was prepared by attaching pt(iv)-cooh to a biodegradable amphiphilic block copolymer containing pendant oh groups. the conjugate can assemble into micelles (m(pt)) with a mean diameter of ca. 169 nm. further, curcumin (cm) was used to sensitize platinum drug based nanoparticles to overcome cisplatin resistance and enhance antitumor efficacy. in vitro studies showed that m(pt)/cm combinations had great synergistic effect both on cisplatin sensitive and cisplatin resistant cell lines (a2780 and a2780ddp). in vivo studies showed that m(pt)/cm had a much lower systemic toxicity and an enhanced antitumor efficacy compared to cisplatin alone or the corresponding cisplatin/cm combinations. therefore, polymer-cisplatin(iv) conjugate with small molecules that serve as a non-cytotoxic or minimally cytotoxic sensitizer or enhancer provide a promising strategy, which may have potential clinical implications in the near future. (c) 2016 elsevier b.v. all rights reserved. |
| WOS关键词 | COMBINATION THERAPY ; ANTITUMOR EFFICACY ; SYSTEMIC TOXICITY ; OVARIAN-CANCER ; CO-DELIVERY ; CISPLATIN(IV) ; MICELLES ; POLYMER ; MECHANISMS ; RESISTANCE |
| WOS研究方向 | Biophysics ; Chemistry ; Materials Science |
| WOS类目 | Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000381171800093 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2376031 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yan, Lesan; Qi, Ruogu |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Union Hosp, Dept Obstet & Gynecol, Tongji Med Coll, Wuhan 430022, Peoples R China 2.Mt Sinai Roosevelt, Dept Med, 1000 Tenth Ave,Suite 3A-02, New York, NY 10019 USA 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kang, Xiang,Zhao, Chen,Yan, Lesan,et al. Sensitizing nanoparticle based platinum(iv) drugs by curcumin for better chemotherapy[J]. Colloids and surfaces b-biointerfaces,2016,145:812-819. |
| APA | Kang, Xiang,Zhao, Chen,Yan, Lesan,Qi, Ruogu,Jing, Xiabin,&Wang, Zehua.(2016).Sensitizing nanoparticle based platinum(iv) drugs by curcumin for better chemotherapy.Colloids and surfaces b-biointerfaces,145,812-819. |
| MLA | Kang, Xiang,et al."Sensitizing nanoparticle based platinum(iv) drugs by curcumin for better chemotherapy".Colloids and surfaces b-biointerfaces 145(2016):812-819. |
| 个性服务 |
| 查看访问统计 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论