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	The ubiquitin ligase trim27 functions as a host restriction factor antagonized by mycobacterium tuberculosis ptpa during mycobacterial infection
	Wang, Jing1; Teng, Jade L. L.2; Zhao, Dongdong1,3; Ge, Pupu1; Li, Bingxi1; Woo, Patrick C. Y.2; Liu, Cui Hua1,3
刊名	Scientific reports
	2016-10-04
卷号	6页码:13
ISSN号	2045-2322
DOI	10.1038/srep34827
通讯作者	Liu, cui hua(liucuihua@im.ac.cn)
英文摘要	Macrophage-mediated innate immune responses play crucial roles in host defense against pathogens. recent years have seen an explosion of host proteins that act as restriction factors blocking viral replication in infected cells. however, the essential factors restricting mycobacterium tuberculosis (mtb) and their regulatory roles during mycobacterial infection remain largely unknown. we previously reported that mtb tyrosine phosphatase ptpa, a secreted effector protein required for intracellular survival of mtb, inhibits innate immunity by co-opting the host ubiquitin system. here, we identified a new ptpa-interacting host protein trim27, which is reported to possess a conserved ring domain and usually acts as an e3 ubiquitin ligase that interferes with various cellular processes. we further demonstrated that trim27 restricts survival of mycobacteria in macrophages by promoting innate immune responses and cell apoptosis. interestingly, mtb ptpa could antagonize trim27-promoted jnk/p38 mapk pathway activation and cell apoptosis through competitively binding to the ring domain of trim27. trim27 probably works as a potential restriction factor for mtb and its function is counteracted by mtb effector proteins such as ptpa. our study suggests a potential tuberculosis treatment via targeting of the trim27-ptpa interfaces.
WOS关键词	RET FINGER PROTEIN ; DEPHOSPHORYLATION ; REPLICATION ; ACTIVATION ; MACROPHAGE ; INHIBITION ; VIRULENCE ; PATHWAY ; COMPLEX ; FAMILY
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000384543400001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375771
专题	中国科学院大学
通讯作者	Liu, Cui Hua
作者单位	1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 2.Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China 3.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 101408, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jing,Teng, Jade L. L.,Zhao, Dongdong,et al. The ubiquitin ligase trim27 functions as a host restriction factor antagonized by mycobacterium tuberculosis ptpa during mycobacterial infection[J]. Scientific reports,2016,6:13.
APA	Wang, Jing.,Teng, Jade L. L..,Zhao, Dongdong.,Ge, Pupu.,Li, Bingxi.,...&Liu, Cui Hua.(2016).The ubiquitin ligase trim27 functions as a host restriction factor antagonized by mycobacterium tuberculosis ptpa during mycobacterial infection.Scientific reports,6,13.
MLA	Wang, Jing,et al."The ubiquitin ligase trim27 functions as a host restriction factor antagonized by mycobacterium tuberculosis ptpa during mycobacterial infection".Scientific reports 6(2016):13.

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