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	A silicon based implantable microelectrode array for electrophysiological and dopamine recording from cortex to striatum in the non-human primate brain
	Zhang, Song1,2; Song, Yilin1,2; Wang, Mixia1,2; Zhang, Zhiming3; Fan, Xinyi1,2; Song, Xianteng1,2; Zhuang, Ping4; Yue, Feng4; Chan, Piu4; Cai, Xinxia1,2
刊名	Biosensors & bioelectronics
	2016-11-15
卷号	85页码:53-61
关键词	Implantable mea Neuroelectrical Neurochemical Da Non-human primate
ISSN号	0956-5663
DOI	10.1016/j.bios.2016.04.087
通讯作者	Chan, piu(pbchan90@gmail.com) ; Cai, xinxia(xxcai@mail.ie.ac.cn)
英文摘要	Dual-mode, multielectrode recordings have become routine in rodent neuroscience research and have recently been adapted to the non-human primate. however, robust and reliable application of acute, multielectrode recording methods in monkeys especially for deep brain nucleus research remains a challenge. in this paper, we described a low cost silicon based 16-site implantable microelectrode array (mea) chip fabricated by standard lithography technology for in vivo test. the array was 25 mm long and designed to use in non-human primate models, for electrophysiological and electrochemical recording. we presented a detailed protocol for array fabrication, then showed that the device can record spikes, lfps and dopamine (da) variation continuously from cortex to striatum in an esthetized monkey. though our experiment, high-quality electrophysiological signals were obtained from the animal. across any given microelectrode, spike amplitudes ranged from 70 to 300 mu v peak to peak, with a mean signal-tonoise ratio of better than 5:1. calibration results showed the mea probe had high sensitivity and good selectivity for da. the da concentration changed from 42.8 to 481.6 mu m when the mea probe inserted from cortex into deep brain nucleus of striatum, which reflected the inhomogeneous distribution of da in brains. compared with existing methods allowing single mode (electrophysiology or electrochemistry) recording. this system is designed explicitly for dual-mode recording to meet the challenges of recording in non-human primates. (c) 2016 elsevier b.v. all rights reserved.
WOS关键词	SPIKE TRAIN DATA ; ELECTRODE ARRAY ; OSCILLATIONS ; NEURONS ; RAT
WOS研究方向	Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
WOS类目	Biophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology
语种	英语
出版者	ELSEVIER ADVANCED TECHNOLOGY
WOS记录号	WOS:000382410100007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375647
专题	中国科学院大学
通讯作者	Chan, Piu; Cai, Xinxia
作者单位	1.Chinese Acad Sci, Inst Elect, State Key Lab Transducer Technol, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 10096, Peoples R China 3.Univ Kentucky, Chandler Med Ctr, Lexington, KY 40536 USA 4.Capital Med Univ, Xuanwu Hosp, Beijing 100053, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Song,Song, Yilin,Wang, Mixia,et al. A silicon based implantable microelectrode array for electrophysiological and dopamine recording from cortex to striatum in the non-human primate brain[J]. Biosensors & bioelectronics,2016,85:53-61.
APA	Zhang, Song.,Song, Yilin.,Wang, Mixia.,Zhang, Zhiming.,Fan, Xinyi.,...&Cai, Xinxia.(2016).A silicon based implantable microelectrode array for electrophysiological and dopamine recording from cortex to striatum in the non-human primate brain.Biosensors & bioelectronics,85,53-61.
MLA	Zhang, Song,et al."A silicon based implantable microelectrode array for electrophysiological and dopamine recording from cortex to striatum in the non-human primate brain".Biosensors & bioelectronics 85(2016):53-61.

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