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	Selenomethionine reduces the deposition of beta-amyloid plaques by modulating beta-secretase and enhancing selenoenzymatic activity in a mouse model of alzheimer's disease
	Zhang, Zhong-Hao1; Chen, Chen2; Wu, Qiu-Yan2; Zheng, Rui2; Liu, Qiong2; Ni, Jia-Zuan1,2; Hoffmann, Peter R.3; Song, Guo-Li2
刊名	Metallomics
	2016-08-01
卷号	8期号:8页码:782-789
ISSN号	1756-5901
DOI	10.1039/c6mt00117c
通讯作者	Song, guo-li(lilys@szu.edu.cn)
英文摘要	Alzheimer's disease (ad) is characterized by the production of large amounts of beta-amyloid (ab) and the accumulation of extracellular senile plaques, which have been considered to be potential targets in the treatment of ad. selenium (se) is a nutritionally essential trace element with known antioxidant potential and se status has been shown to decrease with age and has a close relationship with cognitive competence in ad. selenomethionine (se-met), a major reserve form of se in organisms, has been shown in our previous study to ameliorate the decline in cognitive function, increase oxidation resistance, and reduce tau hyperphosphorylation in a triple transgenic mouse model of ad. however, it has not been reported whether se-met has any effects on a beta pathology in ad mice. to study the effect of se-met on a beta pathology and the function of selenoproteins/selenoenzymes in 3x tg-ad mice, 3x tg-ad mice at 8 months of age were treated with se-met for 3 months. se-met led to significantly reduced production and deposition of a beta, down-regulation of beta-secretase levels and enhanced activity of selenoenzymes as well as increased levels of se in the hippocampus and cortex. se-met reduces amyloidogenic processing of amyloid precursor protein while modulating beta-secretase and selenoenzymatic activity in ad mice. these results indicate that se-met might exert its therapeutic effect through multiple pathways in ad.
WOS关键词	INTRANEURONAL A-BETA ; OXIDATIVE STRESS ; SELENOPROTEIN-P ; TRANSGENIC MICE ; TAU PATHOLOGY ; CASCADE HYPOTHESIS ; COGNITIVE DECLINE ; IN-VIVO ; SELENIUM ; NEURODEGENERATION
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000381416600007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375617
专题	中国科学院大学
通讯作者	Song, Guo-Li
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, Changchun Inst Appl Chem, Changchun, Peoples R China 2.Shenzhen Univ, Shenzhen Key Lab Marine Bioresources & Ecol, Coll Life Sci & Oceanog, Shenzhen, Peoples R China 3.Univ Hawaii, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96822 USA
推荐引用方式 GB/T 7714	Zhang, Zhong-Hao,Chen, Chen,Wu, Qiu-Yan,et al. Selenomethionine reduces the deposition of beta-amyloid plaques by modulating beta-secretase and enhancing selenoenzymatic activity in a mouse model of alzheimer's disease[J]. Metallomics,2016,8(8):782-789.
APA	Zhang, Zhong-Hao.,Chen, Chen.,Wu, Qiu-Yan.,Zheng, Rui.,Liu, Qiong.,...&Song, Guo-Li.(2016).Selenomethionine reduces the deposition of beta-amyloid plaques by modulating beta-secretase and enhancing selenoenzymatic activity in a mouse model of alzheimer's disease.Metallomics,8(8),782-789.
MLA	Zhang, Zhong-Hao,et al."Selenomethionine reduces the deposition of beta-amyloid plaques by modulating beta-secretase and enhancing selenoenzymatic activity in a mouse model of alzheimer's disease".Metallomics 8.8(2016):782-789.

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