| Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the k15 gene of kaposi's sarcoma-associated herpesvirus | |
| Wang, Linding1,2; Pietrek, Marcel1; Brinkmann, Melanie M.1; Haevemeier, Anika1; Fischer, Irina1; Hillenbrand, Bernd1; Dittrich-Breiholz, Oliver3; Kracht, Michael4; Chanas, Simon5; Blackbourn, David J.5 | |
| 刊名 | Journal of general virology
 |
| 2009-05-01 | |
| 卷号 | 90页码:1190-1201 |
| ISSN号 | 0022-1317 |
| DOI | 10.1099/vir.0.007971-0 |
| 通讯作者 | Schulz, thomas f.(schulz.thomas@mh-hannover.de) |
| 英文摘要 | Rhesus monkey rhadinovirus (rrv) is a gamma-2 herpesvirus related to the human kaposi's sarcoma-associated herpesvirus (kshv or human herpesvirus 8). this study identified an alternatively spliced gene at the right side of the rrv genome (strain 17577) between open reading frame 75 and the terminal repeat region. of its eight exons, the first seven encoded up to 12 transmembrane domains, whilst the eighth exon encoded a predicted c-terminal cytoplasmic domain. structurally and positionally, this rrv gene therefore resembles the k15 gene of kshv; it was provisionally named rk15 to avoid confusion with other rrv17577 genes. in ectopic expression studies, the 55 kda rk15 protein isoform activated the jnk and nf-kappa b pathways, like the 45 kda kshv k15-encoded protein isoform. in contrast to k15, which activates angiogenic and inflammatory cytokines such as interleukin (il)-8, il-6 and ccl20, the range of cellular transcripts activated by the rrv k15 homologue was much more restricted, but included il-6, il-8 and fgf21. these data suggest functional differences between terminal membrane proteins at the right end of the genomes of old world primate gamma-2 herpesviruses. |
| WOS关键词 | MULTICENTRIC CASTLEMANS-DISEASE ; PRIMARY EFFUSION LYMPHOMA ; DNA-SEQUENCES ; RETROPERITONEAL FIBROMATOSIS ; MACAQUE RHADINOVIRUSES ; MEMBRANE-PROTEIN ; HUMAN-HERPESVIRUS-8 ; EXPRESSION ; VIRUS ; CELLS |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Virology |
| WOS类目 | Biotechnology & Applied Microbiology ; Virology |
| 语种 | 英语 |
| 出版者 | SOC GENERAL MICROBIOLOGY |
| WOS记录号 | WOS:000266019700016 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2375593 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Schulz, Thomas F. |
| 作者单位 | 1.Hannover Med Sch, Inst Virol, D-30625 Hannover, Germany 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 3.Hannover Med Sch, Inst Biochem, D-30625 Hannover, Germany 4.Hannover Med Sch, Inst Pharmacol, D-30625 Hannover, Germany 5.Univ Birmingham, CRUK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England |
| 推荐引用方式 GB/T 7714 | Wang, Linding,Pietrek, Marcel,Brinkmann, Melanie M.,et al. Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the k15 gene of kaposi's sarcoma-associated herpesvirus[J]. Journal of general virology,2009,90:1190-1201. |
| APA | Wang, Linding.,Pietrek, Marcel.,Brinkmann, Melanie M..,Haevemeier, Anika.,Fischer, Irina.,...&Schulz, Thomas F..(2009).Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the k15 gene of kaposi's sarcoma-associated herpesvirus.Journal of general virology,90,1190-1201. |
| MLA | Wang, Linding,et al."Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the k15 gene of kaposi's sarcoma-associated herpesvirus".Journal of general virology 90(2009):1190-1201. |
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