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	Kaposi's sarcoma-associated herpesvirus latent gene vflip inhibits viral lytic replication through nf-kappa b-mediated suppression of the ap-1 pathway: a novel mechanism of virus control of latency
	Ye, Feng-Chun1,2,6; Zhou, Fu-Chun1,2,6; Xie, Jian-Ping1,2; Kang, Tao1,2,7; Greene, Whitney1,2; Kuhne, Kurt1,3; Lei, Xiu-Fen1,2,6; Li, Qui-Hua1,3; Gao, Shou-Jiang1,2,3,4,5,6,7
刊名	Journal of virology
	2008-05-01
卷号	82期号:9页码:4235-4249
ISSN号	0022-538X
DOI	10.1128/jvi.02370-07
通讯作者	Gao, shou-jiang(gaos@uthscsa.edu)
英文摘要	Kaposi's sarcoma-associated herpesvirus (kshv) latency is central to the evasion of host immune surveillances and induction of kshv-related malignancies. the mechanism of kshv latency remains unclear. here, we show that the ksrv latent gene vflip promotes viral latency by inhibiting viral lytic replication. vflip suppresses the ap-1 pathway, which is essential for kshv lytic replication, by activating the nf-kappa b pathway. thus, by manipulating two convergent cellular pathways, vflip regulates both cell survival and kshv lytic replication to promote viral latency. these results also indicate that the effect of the nf-kappa b pathway on kshv replication is determined by the status of the ap-1 pathway and hence provide a mechanistic explanation for the contradictory role of the nf-kappa b pathway in kshv replication. since the nf-kappa b pathway is commonly activated during infection of gammaherpesviruses, these findings might have general implications for the control of gammaherpesviral latency.
WOS关键词	PROTEIN-KINASE PATHWAYS ; NUCLEAR ANTIGEN ; ENDOTHELIAL-CELLS ; PRIMARY INFECTION ; DNA-SEQUENCES ; MICRORNA CLUSTER ; JNK ACTIVATION ; EXPRESSION ; HUMAN-HERPESVIRUS-8 ; REACTIVATION
WOS研究方向	Virology
WOS类目	Virology
语种	英语
出版者	AMER SOC MICROBIOLOGY
WOS记录号	WOS:000255084600005
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375524
专题	武汉病毒研究所
通讯作者	Gao, Shou-Jiang
作者单位	1.Univ Texas Hlth Sci Ctr San Antonio, Tumor Virol Program, Greehey Childrens Canc Res Inst, San Antonio, TX 78229 USA 2.Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, San Antonio, TX 78229 USA 3.Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA 4.Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, San Antonio, TX 78229 USA 5.Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA 6.Univ Texas Hlth Sci Ctr San Antonio, Canc Treatment & Res Ctr, San Antonio, TX 78229 USA 7.Chinese Acad Sci, Wuhan Inst Virol, Wuhan, Peoples R China
推荐引用方式 GB/T 7714	Ye, Feng-Chun,Zhou, Fu-Chun,Xie, Jian-Ping,et al. Kaposi's sarcoma-associated herpesvirus latent gene vflip inhibits viral lytic replication through nf-kappa b-mediated suppression of the ap-1 pathway: a novel mechanism of virus control of latency[J]. Journal of virology,2008,82(9):4235-4249.
APA	Ye, Feng-Chun.,Zhou, Fu-Chun.,Xie, Jian-Ping.,Kang, Tao.,Greene, Whitney.,...&Gao, Shou-Jiang.(2008).Kaposi's sarcoma-associated herpesvirus latent gene vflip inhibits viral lytic replication through nf-kappa b-mediated suppression of the ap-1 pathway: a novel mechanism of virus control of latency.Journal of virology,82(9),4235-4249.
MLA	Ye, Feng-Chun,et al."Kaposi's sarcoma-associated herpesvirus latent gene vflip inhibits viral lytic replication through nf-kappa b-mediated suppression of the ap-1 pathway: a novel mechanism of virus control of latency".Journal of virology 82.9(2008):4235-4249.

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