| Down-regulation of risa improves insulin sensitivity by enhancing autophagy | |
| Wang, Yuangao1; Hu, Yanan1; Sun, Chenxia1; Zhuo, Shu1; He, Zhishui1; Wang, Hui1; Yan, Menghong1; Liu, Jun1; Luan, Yi1; Dai, Changgui1 | |
| 刊名 | Faseb journal
 |
| 2016-09-01 | |
| 卷号 | 30期号:9页码:3133-3145 |
| 关键词 | Lncrna Insulin resistance Glucose homeostasis Ob Ob mice |
| ISSN号 | 0892-6638 |
| DOI | 10.1096/fj.201500058r |
| 通讯作者 | Zhai, qiwei(qwzhai@sibs.ac.cn) |
| 英文摘要 | It has been reported that some small noncoding rnas are involved in the regulation of insulin sensitivity. however, whether long noncoding rnas also participate in the regulation of insulin sensitivity is still largely unknown. we identified and characterized a long noncoding rna, regulator of insulin sensitivity and autophagy (risa), which is a poly(a)(+) cytoplasmic rna. overexpression of risa in mouse primary hepatocytes or c2c12 myotubes attenuated insulin-stimulated phosphorylation of insulin receptor, akt, and gsk3, and knockdown of risa alleviated insulin resistance. further studies showed that overexpression of risa in hepatocytes or myotubes decreased autophagy, and knockdown of risa up-regulated autophagy. moreover, knockdown of atg7 or -5 significantly inhibited the effect of knockdown of risa on insulin resistance, suggesting that knockdown of risa alleviated insulin resistance via enhancing autophagy. in addition, tail vein injection of adenovirus to knock down risa enhanced insulin sensitivity and hepatic autophagy in both c57bl/6 and ob/ob mice. taken together, the data demonstrate that risa regulates insulin sensitivity by affecting autophagy and suggest that risa is a potential target for treating insulin-resistance-related diseases.wang, y., hu, y., sun, c., zhuo, s., he, z., wang, h., yan, m., liu, j., luan, y., dai, c., yang, y., huang, r., zhou, b., zhang, f., zhai, q. down-regulation of risa improves insulin sensitivity by enhancing autophagy. |
| WOS关键词 | LONG NONCODING RNAS ; ACTIVATES AUTOPHAGY ; ADENOVIRAL VECTORS ; METABOLISM ; RESISTANCE ; DISEASE ; SIRT1 ; MICE ; PHOSPHORYLATION ; OBESITY |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Biology ; Cell Biology |
| 语种 | 英语 |
| 出版者 | FEDERATION AMER SOC EXP BIOL |
| WOS记录号 | WOS:000382816300014 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2375436 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhai, Qiwei |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci,Inst Nutr Sci, Key Lab Nutr & Metab,Shanghai Inst Biol Sci, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yuangao,Hu, Yanan,Sun, Chenxia,et al. Down-regulation of risa improves insulin sensitivity by enhancing autophagy[J]. Faseb journal,2016,30(9):3133-3145. |
| APA | Wang, Yuangao.,Hu, Yanan.,Sun, Chenxia.,Zhuo, Shu.,He, Zhishui.,...&Zhai, Qiwei.(2016).Down-regulation of risa improves insulin sensitivity by enhancing autophagy.Faseb journal,30(9),3133-3145. |
| MLA | Wang, Yuangao,et al."Down-regulation of risa improves insulin sensitivity by enhancing autophagy".Faseb journal 30.9(2016):3133-3145. |
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