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	Periaqueductal gray neuronal activities underlie different aspects of defensive behaviors
	Deng, Hanfei1,2; Xiao, Xiong1,2; Wang, Zuoren1
刊名	Journal of neuroscience
	2016-07-20
卷号	36期号:29页码:7580-7588
关键词	Defensive behavior Electrophysiology Innate behavior Optogenetics Periaqueductal gray
ISSN号	0270-6474
DOI	10.1523/jneurosci.4425-15.2016
通讯作者	Wang, zuoren(zuorenwang@ion.ac.cn)
英文摘要	Defense is a basic survival mechanism when animals face danger. previous studies have suggested that the midbrain periaqueductal gray (pag) is essential for the generation of defensive reactions. here we showed that optogenetic activation of neurons in the pag in mice was sufficient to induce a series of defensive responses (including running, freezing, and avoidance). however, the endogenous neural dynamics of the pag underlying defensive behaviors still remain elusive. using chronic extracellular recording, we recorded the spiking activities of pag neurons in freely behaving mice exposed to natural threats (rats). we observed that there exist distinct neuronal subsets within the pag participating in respective detection (risk assessment) and response (flight) aspects of defensive behaviors. our results demonstrate the important role of pag neuronal activities in the control of different aspects of defensive behaviors, and provide novel insights for investigating defense from an electrophysiological perspective.
WOS关键词	DORSAL PREMAMMILLARY NUCLEUS ; VENTROMEDIAL HYPOTHALAMUS ; RATS ; FEAR ; PREDATOR ; ORGANIZATION ; STIMULATION ; MIDBRAIN ; AGGRESSION ; AMYGDALA
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
语种	英语
出版者	SOC NEUROSCIENCE
WOS记录号	WOS:000382296300004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375349
专题	中国科学院大学
通讯作者	Wang, Zuoren
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Neurosci,State Key Lab Neurosci, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Deng, Hanfei,Xiao, Xiong,Wang, Zuoren. Periaqueductal gray neuronal activities underlie different aspects of defensive behaviors[J]. Journal of neuroscience,2016,36(29):7580-7588.
APA	Deng, Hanfei,Xiao, Xiong,&Wang, Zuoren.(2016).Periaqueductal gray neuronal activities underlie different aspects of defensive behaviors.Journal of neuroscience,36(29),7580-7588.
MLA	Deng, Hanfei,et al."Periaqueductal gray neuronal activities underlie different aspects of defensive behaviors".Journal of neuroscience 36.29(2016):7580-7588.

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