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	Targeting dengue virus ns4b protein for drug discovery
	Xie, Xuping1; Zou, Jing1,2,3; Wang, Qing-Yin1; Shi, Pei-Yong1
刊名	Antiviral research
	2015-06-01
卷号	118页码:39-45
关键词	Flavivirus Dengue Nonstructural protein 4b Ns4b Antivirals
ISSN号	0166-3542
DOI	10.1016/j.antiviral.2015.03.007
通讯作者	Wang, qing-yin(qing_yin.wang@novartis.com)
英文摘要	The flavivirus nonstructural 4b protein (ns4b) has recently emerged as a valid antiviral target for drug discovery. here we review (i) the current understanding of the structure and function of denv ns4b, (ii) the approaches that have been taken to identify ns4b inhibitors, and (iii) the known inhibitors of flavivirus ns4b protein. this article forms part of a symposium in antiviral research on flavivirus drug discovery. (c) 2015 elsevier b.v. all rights reserved.
WOS关键词	WEST-NILE-VIRUS ; NONSTRUCTURAL PROTEINS ; CRYSTAL-STRUCTURE ; MEMBRANE-ALTERATIONS ; REPLICATION COMPLEX ; CATALYTIC DOMAIN ; RNA REPLICATION ; STRANDED-RNA ; INHIBITION ; NS3
WOS研究方向	Pharmacology & Pharmacy ; Virology
WOS类目	Pharmacology & Pharmacy ; Virology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000355037500005
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375176
专题	武汉病毒研究所
通讯作者	Wang, Qing-Yin
作者单位	1.Novartis Inst Trop Dis, Singapore 138670, Singapore 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Beijing 100864, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Xie, Xuping,Zou, Jing,Wang, Qing-Yin,et al. Targeting dengue virus ns4b protein for drug discovery[J]. Antiviral research,2015,118:39-45.
APA	Xie, Xuping,Zou, Jing,Wang, Qing-Yin,&Shi, Pei-Yong.(2015).Targeting dengue virus ns4b protein for drug discovery.Antiviral research,118,39-45.
MLA	Xie, Xuping,et al."Targeting dengue virus ns4b protein for drug discovery".Antiviral research 118(2015):39-45.

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