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	A quick-responsive dna nanotechnology device for bio-molecular homeostasis regulation
	Wu, Songlin1,2; Wang, Pei2,3,4,5,6; Xiao, Chen2,3; Li, Zheng2,4,5,6,7; Yang, Bing1,2,4,5,6; Fu, Jieyang1,2; Chen, Jing2,4,5,6,7; Wan, Neng2,4,5,6,7; Ma, Cong3,4,5,6,8; Li, Maoteng1,8
刊名	Scientific reports
	2016-08-10
卷号	6页码:10
ISSN号	2045-2322
DOI	10.1038/srep31379
通讯作者	Li, maoteng(limaoteng426@hust.edu.cn) ; Yang, xiangliang(yangxl@hust.edu.cn) ; Zhan, yi(zhanyi@hust.edu.cn)
英文摘要	Physiological processes such as metabolism, cell apoptosis and immune responses, must be strictly regulated to maintain their homeostasis and achieve their normal physiological functions. the speed with which bio-molecular homeostatic regulation occurs directly determines the ability of an organism to adapt to conditional changes. to produce a quick-responsive regulatory system that can be easily utilized for various types of homeostasis, a device called nano-fingers that facilitates the regulation of physiological processes was constructed using dna origami nanotechnology. this nano-fingers device functioned in linked open and closed phases using two types of dna tweezers, which were covalently coupled with aptamers that captured specific molecules when the tweezer arms were sufficiently close. via this specific interaction mechanism, certain physiological processes could be simultaneously regulated from two directions by capturing one biofactor and releasing the other to enhance the regulatory capacity of the device. to validate the universal application of this device, regulation of the homeostasis of the blood coagulant thrombin was attempted using the nano-fingers device. it was successfully demonstrated that this nano-fingers device achieved coagulation buffering upon the input of fuel dna. this nano-device could also be utilized to regulate the homeostasis of other types of bio-molecules.
WOS关键词	PROTEIN-BINDING ; STRANDED-DNA ; NANOSCALE SHAPES ; HUMAN THROMBIN ; FOLDING DNA ; LABEL-FREE ; ORIGAMI ; NANOSTRUCTURES ; COAGULATION ; DYNAMICS
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000381107500001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375111
专题	中国科学院大学
通讯作者	Li, Maoteng; Yang, Xiangliang; Zhan, Yi
作者单位	1.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Dept Biotechnol, Wuhan 430074, Peoples R China 2.Huazhong Univ Sci & Technol, Qiming Coll, Innovat Base Life Sci & Technol, Wuhan 430074, Peoples R China 3.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Dept Nanomed & Biopharmaceut, Wuhan 430074, Peoples R China 4.Huazhong Univ Sci & Technol, Bei Shizhang Adv Class Life Sci Res, Wuhan 430074, Peoples R China 5.Chinese Acad Sci, Inst Biophys, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Natl Educ Base Biosci, Wuhan 430074, Peoples R China 8.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Key Lab Mol Biophys, Minist Educ, Wuhan 430074, Peoples R China 9.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Student Affair Off, Wuhan 430074, Peoples R China
推荐引用方式 GB/T 7714	Wu, Songlin,Wang, Pei,Xiao, Chen,et al. A quick-responsive dna nanotechnology device for bio-molecular homeostasis regulation[J]. Scientific reports,2016,6:10.
APA	Wu, Songlin.,Wang, Pei.,Xiao, Chen.,Li, Zheng.,Yang, Bing.,...&Zhan, Yi.(2016).A quick-responsive dna nanotechnology device for bio-molecular homeostasis regulation.Scientific reports,6,10.
MLA	Wu, Songlin,et al."A quick-responsive dna nanotechnology device for bio-molecular homeostasis regulation".Scientific reports 6(2016):10.

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