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	In vivo targeting and imaging of atherosclerosis using multifunctional virus-like particles of simian virus 40
	Sun, Xianxun1,3,4; Li, Wei1; Zhang, Xiaowei1; Qi, Mi1,3; Zhang, Zhiping1; Zhang, Xian-En2; Cui, Zongqiang1
刊名	Nano letters
	2016-10-01
卷号	16期号:10页码:6164-6171
关键词	Sv40 multifunctional nanoparticle In vivo targeted imaging Quantum dots Hirulog Atherosclerosis
ISSN号	1530-6984
DOI	10.1021/acs.nanolett.6b02386
通讯作者	Zhang, xian-en(zhangxe@ibp.ac.cn) ; Cui, zongqiang(czq@wh.iov.cn)
英文摘要	Atherosclerosis, is-fa leading cause of death globally. targeted imaging and 'therapeutics are desirable for the detection and treatment of the disease. in this study, we developed trifunctional simian virus 40 (sv40)-based nanoparticles for in vivo targeting and imaging of atherosclerotic plaques. these novel trifunctional sv40-based nanopartides encapsulate near-infrared-quantum dots and bear a targeting element and a drug, component. using trifunctional sv40-based nanoparticles, we were able to noninvasively fluorescently-image atherosclerotic plaques in live intact apoe(-/-) mice. near-infrared quantum dots encapsulated: in the sv40 virus-like particles showed prominent optical properties for in vivo imaging. when different targeting peptides for vascular tell adhesion molecule-1, macrophages, and fibrin were used; early, developmental, and late stages of atherosclerosis.could be targeted and imaged in live intact apoe(-/-) mice respectively. targeted sv40 virus-like particles,also-clelivered an increased concentration of the anticoagulant drug hirulog to atherosclerosis plaques. our study provided :novel sv40-based nanopatticles with multivalency and intiltifunttionality suitable for in imaging, molecular targeting, and-drug delivery in atherosclerosis.
WOS关键词	MAGNETIC-RESONANCE ; CONTRAST AGENT ; PLAQUES ; MACROPHAGES ; PEPTIDE ; NANOMEDICINE ; FLUORESCENCE ; PATHOGENESIS ; INFLAMMATION ; PLATFORM
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000385469800027
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374899
专题	中国科学院大学
通讯作者	Zhang, Xian-En; Cui, Zongqiang
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Natl Lab Biomacromol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Jiang Han Univ, Coll Life Sci, Wuhan 430056, Peoples R China
推荐引用方式 GB/T 7714	Sun, Xianxun,Li, Wei,Zhang, Xiaowei,et al. In vivo targeting and imaging of atherosclerosis using multifunctional virus-like particles of simian virus 40[J]. Nano letters,2016,16(10):6164-6171.
APA	Sun, Xianxun.,Li, Wei.,Zhang, Xiaowei.,Qi, Mi.,Zhang, Zhiping.,...&Cui, Zongqiang.(2016).In vivo targeting and imaging of atherosclerosis using multifunctional virus-like particles of simian virus 40.Nano letters,16(10),6164-6171.
MLA	Sun, Xianxun,et al."In vivo targeting and imaging of atherosclerosis using multifunctional virus-like particles of simian virus 40".Nano letters 16.10(2016):6164-6171.

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