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	Preparation and self-assembly of ph-sensitive amphiphilic comb-shaped copolymer containing long fluorinated side chains
	Tan, Jianquan1,2,3; Liu, Weiqu1,2; Wang, Zhengfang1,2
刊名	Journal of macromolecular science part a-pure and applied chemistry
	2016
卷号	53期号:11页码:716-724
关键词	Ph-sensitive Amphiphilic comb-shaped copolymer Self-assembly Fluorinated side chains Cytotoxicity
ISSN号	1060-1325
DOI	10.1080/10601325.2016.1224630
通讯作者	Liu, weiqu(liuwq@gic.ac.cn)
英文摘要	Novel ph-sensitive amphiphilic comb-shaped copolymers containing long fluorinated side chains, which combined the characteristics of ph-sensitivity from pendent tertiary amine groups, unique hydrophobic and fluorophobic characteristic from the fluorinated moieties and hydrophilicity from the poly (ethylene glycol) segments, were designed and synthesized via radical polymerizaion of 2-(dimethylamino) ethyl methacrylate (dmaema), poly (ethylene glycol) methyl ether methacrylate (pegma) and homemade fluorinated macromonomer (phfbma-gma). the physicochemical properties of polymeric micelles prepared therefrom were investigated. the chemical structures of the copolymers were characterized by gpc, ftir and h-1-nmr. the critical micelle concentrations (cmc) of the copolymers in different ph (5.0 and 7.4) were determined by fluorescence spectroscopy. larger cmcs could be obtained in lower ph since the pronation of dmaema moieties enhanced the hydrophilicity. with increasing the amount, as well as the molecular weight, of phfbma-gma, cmc decreased significantly. as ph decreased, particle size, as well as zeta potential of the polymeric micelles increased significantly, indicating significant ph-sensitivity of the polymeric micelles. furthermore, larger polymeric micelles were obtained with larger amount, as well as higher molecular weight, of phfbma-gma. transmission electron microscopy (tem) showed that the morphological shapes of the copolymers performed spherical micelles. the cytotoxicity test showed that the comb-shaped copolymers performed extremely low cytotoxicity. the ph-sensitive polymeric micelles prepared from the amphiphilic comb-shaped copolymers containing long fluorinated side chains could be potential candidates for nanotanks for hydrophobic or fluorophobic molecules and drug carriers and the facile preparation might fit for large scale industrialization.
WOS关键词	LOW SURFACE-ENERGY ; GRAFT-COPOLYMERS ; HYDROPHOBIC BACKBONE ; HYDROPHILIC BRANCHES ; METHACRYLATE)-G-POLY(METHYL METHACRYLATE) ; BLOCK-COPOLYMERS ; AQUEOUS-SOLUTION ; DRUG-DELIVERY ; MICELLES ; POLYMERIZATION
WOS研究方向	Polymer Science
WOS类目	Polymer Science
语种	英语
出版者	TAYLOR & FRANCIS INC
WOS记录号	WOS:000385564600009
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374824
专题	中国科学院大学
通讯作者	Liu, Weiqu
作者单位	1.Chinese Acad Sci, Guangzhou Inst Chem, Guangzhou 510650, Guangdong, Peoples R China 2.Chinese Acad Sci, Key Lab Cellulose & Lignocellulos Chem, Guangzhou, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Tan, Jianquan,Liu, Weiqu,Wang, Zhengfang. Preparation and self-assembly of ph-sensitive amphiphilic comb-shaped copolymer containing long fluorinated side chains[J]. Journal of macromolecular science part a-pure and applied chemistry,2016,53(11):716-724.
APA	Tan, Jianquan,Liu, Weiqu,&Wang, Zhengfang.(2016).Preparation and self-assembly of ph-sensitive amphiphilic comb-shaped copolymer containing long fluorinated side chains.Journal of macromolecular science part a-pure and applied chemistry,53(11),716-724.
MLA	Tan, Jianquan,et al."Preparation and self-assembly of ph-sensitive amphiphilic comb-shaped copolymer containing long fluorinated side chains".Journal of macromolecular science part a-pure and applied chemistry 53.11(2016):716-724.

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