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	Controllable drug release system based on phase change molecules as gatekeepers for bimodal tumor therapy with enhanced efficacy
	He, Fei1,2; Chen, Yinyin1,2; Li, Chunxia1; Deng, Xiaoran1,2; Liu, Bin1; Liu, Bei1,2; Huang, Shanshan1; Hou, Zhiyao1; Cheng, Ziyong1; Lin, Jun1
刊名	Rsc advances
	2016
卷号	6期号:70页码:65600-65606
ISSN号	2046-2069
DOI	10.1039/c6ra10736b
通讯作者	Li, chunxia(cxli@ciac.ac.cn) ; Lin, jun(jlin@ciac.ac.cn)
英文摘要	A mixture of anticancer drug doxorubicin hydrochloride (dox) and 1-tetradecanol (td) are co-loaded into core-shell structured cu9s5@msio(2) nanoparticles to achieve bimodal tumor therapy with enhanced efficacy. td, a kind of phase change molecule with a melting temperature (t-m) of 39 degrees c, acts as a gatekeeper to control dox release. cu9s5 is a kind of good photothermal agent and has the advantage of a high photothermal conversion efficiency, which has a thermal effect on td. cu9s5 ncs at a concentration of 312.5 ppm can elevate its temperature by 28.6 degrees c in 5 min when the system is irradiated by a 980 nm laser (0.5 w cm(-2)). when the temperature of the system is higher than 39 degrees c, td can melt and dox will release from the pores. besides nir-triggered release, the dox release is also controlled by ph. synergistic nir-triggered and ph-triggered dox release prevents the premature release of drug molecules (<4% of the whole loaded dox in 24 h) in neutral conditions without irradiation. however, upon irradiation in acidic conditions (ph = 5.0), the release of the whole loaded dox could reach 32.6%. therefore, this versatile combination of photothermal therapy and chemotherapy makes the application of multifunctional drug delivery systems possible.
WOS关键词	MESOPOROUS SILICA NANOPARTICLES ; CHEMO-PHOTOTHERMAL THERAPY ; QUANTUM-DOT-MICELLES ; RAMAN-SCATTERING ; GOLD NANOCAGES ; SHELL ; DELIVERY ; CORE ; CANCER ; NANOCOMPOSITES
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000379577800037
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374697
专题	中国科学院大学
通讯作者	Li, Chunxia; Lin, Jun
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	He, Fei,Chen, Yinyin,Li, Chunxia,et al. Controllable drug release system based on phase change molecules as gatekeepers for bimodal tumor therapy with enhanced efficacy[J]. Rsc advances,2016,6(70):65600-65606.
APA	He, Fei.,Chen, Yinyin.,Li, Chunxia.,Deng, Xiaoran.,Liu, Bin.,...&Lin, Jun.(2016).Controllable drug release system based on phase change molecules as gatekeepers for bimodal tumor therapy with enhanced efficacy.Rsc advances,6(70),65600-65606.
MLA	He, Fei,et al."Controllable drug release system based on phase change molecules as gatekeepers for bimodal tumor therapy with enhanced efficacy".Rsc advances 6.70(2016):65600-65606.

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