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	808 nm light-triggered and hyaluronic acid-targeted dual-photosensitizers nanoplatform by fully utilizing nd3(+)-sensitized upconversion emission with enhanced anti-tumor efficacy
	Hou, Zhiyao1; Deng, Kerong1,3; Li, Chunxia1; Deng, Xiaoran1,3; Lian, Hongzhou1; Cheng, Ziyong1; Jin, Dayong2; Lin, Jun1
刊名	Biomaterials
	2016-09-01
卷号	101页码:32-46
关键词	Photodynamic therapy 808 nm light Hyaluronic acid target Nd3(+)-sensitized upconversion nanoparticles Dual-photosensitizers nanoplatform
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2016.05.024
通讯作者	Li, chunxia(cxli@ciac.ac.cn) ; Lin, jun(jlin@ciac.ac.cn)
英文摘要	The current near-infrared (nir) light-induced photodynamic therapy (pdt) can enhance the tissue penetration depth to trigger photosensitizers (pss) far from the surface. nir-mediated pdt is still challenged by overheating effect on normal tissues, limited" tumor selectivity and low reactive oxygen species (ros) yields. here we construct a dual-agent photosensitizing nanoplatform by combining uv blue upconversion emitting nayf4:yb/tm@nayf4:yb@nandf4:yb@nayf4 (labeled as ucnps) multi shell nanocrystals with titanium dioxide (tio2, uv-light-excited ps) and hypocrellin a (ha, blue-light excited ps), which can induce cancer cell' apoptosis by 808 nm light-triggered and hyaluronic acid (hyal)-targeted pdt. in this construction strategy, the crystallized tio2 shells on the surface of ucnps can play dual roles as uv-light excited ps and conjugation site for hyal, and then hyal is served as targetingligand as well as the carrier of ha simultaneously. the step-by-step reactive mode of loading pss and modifying targeting-ligands is a controllable and ordered design based on the use of one intermediate product as the reaction site for the next component. the nd3(+)-sensitized ucnps with quenching reduction layer can efficiently convert 808 nm nir light to uv-blue emission for simultaneous activation of two pss with enhanced intracellular ros generation. through the in vitro and in vivo experiment results, the dual-photosensitizers nanoplatform presents enhanced anti-tumor efficacy by effective targeting cellular uptake and taking full advantage of upconversion emission, which may make a major step toward next generation of nir-mediated pdt. (c) 2016 elsevier ltd. all rights reserved.
WOS关键词	NEAR-INFRARED LIGHT ; SINGLET OXYGEN GENERATION ; VIVO PHOTODYNAMIC THERAPY ; CORE-SHELL NANOPARTICLES ; UPCONVERTING NANOPARTICLES ; EMERGING APPLICATIONS ; SURFACE MODIFICATION ; ENERGY MIGRATION ; HIGHLY EFFICIENT ; CANCER-THERAPY
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000379632500004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374678
专题	中国科学院大学
通讯作者	Li, Chunxia; Lin, Jun
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China 2.Univ Technol Sydney, Fac Sci, Inst Biomed Mat & Devices, Sydney, NSW 2007, Australia 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Hou, Zhiyao,Deng, Kerong,Li, Chunxia,et al. 808 nm light-triggered and hyaluronic acid-targeted dual-photosensitizers nanoplatform by fully utilizing nd3(+)-sensitized upconversion emission with enhanced anti-tumor efficacy[J]. Biomaterials,2016,101:32-46.
APA	Hou, Zhiyao.,Deng, Kerong.,Li, Chunxia.,Deng, Xiaoran.,Lian, Hongzhou.,...&Lin, Jun.(2016).808 nm light-triggered and hyaluronic acid-targeted dual-photosensitizers nanoplatform by fully utilizing nd3(+)-sensitized upconversion emission with enhanced anti-tumor efficacy.Biomaterials,101,32-46.
MLA	Hou, Zhiyao,et al."808 nm light-triggered and hyaluronic acid-targeted dual-photosensitizers nanoplatform by fully utilizing nd3(+)-sensitized upconversion emission with enhanced anti-tumor efficacy".Biomaterials 101(2016):32-46.

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