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	Direct nucleophilic difluoromethylation of carbonyl compounds
	Deng, Zuyong; Lin, Jin-Hong; Cai, Ji; Xiao, Ji-Chang1
刊名	Organic letters
	2016-07-01
卷号	18期号:13页码:3206-3209
ISSN号	1523-7060
DOI	10.1021/acs.orglett.6b01425
通讯作者	Xiao, ji-chang(jchxiao@sioc.ac.cn)
英文摘要	Phosphonium salt ([ph3p+cf2h] br-, dfpb) was found to be an efficient nucleophilic difluoromethylation reagent. although dfpb is known as a phosphonium ylide precursor, its reaction with carbonyl compounds under traditional "wittig reaction conditions" did not give the expected wittig difluoroolefinated products, but afforded the nucleophilic difluoromethylation products, alpha-cf2h alcohols. mechanistic investigation reveals that the unexpected transformation proceeded via the direct transfer of the cf2h group, which resulted from the high p-o affinity.
WOS关键词	QUATERNARY PHOSPHONIUM HYDROXIDES ; COPPER-MEDIATED DIFLUOROMETHYLATION ; SUBSTITUTION REACTIONS ; WITTIG REACTION ; DECOMPOSITION ; SALTS ; ALDEHYDES ; IODIDES ; REAGENT ; DIFLUOROCARBENE
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000379455300042
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374545
专题	中国科学院大学
通讯作者	Xiao, Ji-Chang
作者单位	1.Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Deng, Zuyong,Lin, Jin-Hong,Cai, Ji,et al. Direct nucleophilic difluoromethylation of carbonyl compounds[J]. Organic letters,2016,18(13):3206-3209.
APA	Deng, Zuyong,Lin, Jin-Hong,Cai, Ji,&Xiao, Ji-Chang.(2016).Direct nucleophilic difluoromethylation of carbonyl compounds.Organic letters,18(13),3206-3209.
MLA	Deng, Zuyong,et al."Direct nucleophilic difluoromethylation of carbonyl compounds".Organic letters 18.13(2016):3206-3209.

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