| Mir-182 regulates metabolic homeostasis by modulating glucose utilization in muscle | |
| Zhang, Duo1; Li, Yan1; Yao, Xuan1; Wang, Hui1; Zhao, Lei2; Jiang, Haowen3; Yao, Xiaohan1; Zhang, Shengjie1; Ye, Cheng1; Liu, Wei1 | |
| 刊名 | Cell reports
 |
| 2016-07-19 | |
| 卷号 | 16期号:3页码:757-768 |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2016.06.040 |
| 通讯作者 | Jin, zi-bing(jinzb@mail.eye.ac.cn) ; Ying, hao(yinghao@sibs.ac.cn) |
| 英文摘要 | Understanding the fiber-type specification and metabolic switch in skeletal muscle provides insights into energy metabolism in physiology and diseases. here, we show that mir-182 is highly expressed in fast-twitch muscle and negatively correlates with blood glucose level. mir-182 knockout mice display muscle loss, fast-to-slow fiber-type switching, and impaired glucose metabolism. mechanistic studies reveal that mir-182 modulates glucose utilization in muscle by targeting foxo1 and pdk4, which control fuel selection via the pyruvate dehydrogenase complex (pdhc). short-term high-fat diet (hfd) feeding reduces muscle mir-182 levels by tumor necrosis factor alpha (tnf alpha), which contributes to the upregulation of foxo1/pdk4. restoration of mir-182 expression in hfd-fed mice induces a faster muscle phenotype, decreases muscle foxo1/pdk4 levels, and improves glucose metabolism. together, our work establishes mir-182 as a critical regulator that confers robust and precise controls on fuel usage and glucose homeostasis. our study suggests that a metabolic shift toward a faster and more glycolytic phenotype is beneficial for glucose control. |
| WOS关键词 | HIGH-FAT DIET ; SKELETAL-MUSCLE ; INSULIN-RESISTANCE ; GENE-EXPRESSION ; MICRORNAS ; FOXO3 ; FLEXIBILITY ; DYSFUNCTION ; CONVERSION ; PATHWAYS |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000380264200015 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2374495 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Jin, Zi-Bing; Ying, Hao |
| 作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Food Safety Res,Inst Nutr Sci, Shanghai 200031, Peoples R China 2.Fudan Univ, Childrens Hosp, Dept Neuromuscular Dis, Shanghai 201102, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Xuhui Cent Hosp, Shanghai Clin Ctr, Shanghai 200031, Peoples R China 5.Fudan Univ, Zhongshan Hosp, Dept Orthoped Surg, Shanghai 200031, Peoples R China 6.Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai 200031, Peoples R China 7.Fudan Univ, Huandong Hosp, Dept Orthoped Surg, Shanghai 200040, Peoples R China 8.Fudan Univ, Ctr Canc, Dept Head & Neck Surg, Shanghai 200032, Peoples R China 9.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China 10.Fudan Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Minist Educ,Key Lab Metab & Mol Med, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Duo,Li, Yan,Yao, Xuan,et al. Mir-182 regulates metabolic homeostasis by modulating glucose utilization in muscle[J]. Cell reports,2016,16(3):757-768. |
| APA | Zhang, Duo.,Li, Yan.,Yao, Xuan.,Wang, Hui.,Zhao, Lei.,...&Ying, Hao.(2016).Mir-182 regulates metabolic homeostasis by modulating glucose utilization in muscle.Cell reports,16(3),757-768. |
| MLA | Zhang, Duo,et al."Mir-182 regulates metabolic homeostasis by modulating glucose utilization in muscle".Cell reports 16.3(2016):757-768. |
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