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	Human cytomegalovirus tegument protein ul82 inhibits sting-mediated signaling to evade antiviral immunity
	Fu, Yu-Zhi1; Su, Shan2; Gao, Yi-Qun1; Wang, Pei-Pei2; Huang, Zhe-Fu3; Hu, Ming-Ming2; Luo, Wei-Wei2; Li, Shu1; Luo, Min-Hua3; Wang, Yan-Yi3
刊名	Cell host & microbe
	2017-02-08
卷号	21期号:2页码:231-243
ISSN号	1931-3128
DOI	10.1016/j.chom.2017.01.001
通讯作者	Shu, hong-bing(shuh@whu.edu.cn)
英文摘要	Recognition of human cytomegalovirus (hcmv) dna by the cytosolic sensor cgas initiates sting-dependent innate antiviral responses. hcmv can antagonize host immune responses to promote latency infection. however, it is unknown whether and how hcmv targets the cgas-sting axis for immune evasion. here we identified the hcmv tegument protein ul82 as a negative regulator of sting-dependent antiviral responses. ul82 interacted with sting and impaired sting-mediated signaling via two mechanisms. ul82 inhibited the translocation of sting from the er to perinuclear microsomes by disrupting the sting-irhom2-trap beta translocation complex. ul82 also impaired the recruitment of tbk1 and irf3 to the sting complex. the levels of downstream antiviral genes induced by ul82-deficient hcmv were higher than those induced by wild-type hcmv. conversely, wild-type hcmv replicated more efficiently than the ul82-deficient mutant. these findings reveal an important mechanism of immune evasion by hcmv.
WOS关键词	EARLY GENE-EXPRESSION ; DNA-SENSING PATHWAY ; KAPPA-B ACTIVATION ; INNATE IMMUNE ; VIRION PROTEIN ; INFECTED-CELLS ; PP71 PROTEIN ; SENSOR CGAS ; VIRUS ; ADAPTER
WOS研究方向	Microbiology ; Parasitology ; Virology
WOS类目	Microbiology ; Parasitology ; Virology
语种	英语
出版者	CELL PRESS
WOS记录号	WOS:000396373400014
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373468
专题	武汉病毒研究所
通讯作者	Shu, Hong-Bing
作者单位	1.Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China 2.Wuhan Univ, Med Res Inst, Sch Med, Collaborat Innovat Ctr Viral Immunol, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Fu, Yu-Zhi,Su, Shan,Gao, Yi-Qun,et al. Human cytomegalovirus tegument protein ul82 inhibits sting-mediated signaling to evade antiviral immunity[J]. Cell host & microbe,2017,21(2):231-243.
APA	Fu, Yu-Zhi.,Su, Shan.,Gao, Yi-Qun.,Wang, Pei-Pei.,Huang, Zhe-Fu.,...&Shu, Hong-Bing.(2017).Human cytomegalovirus tegument protein ul82 inhibits sting-mediated signaling to evade antiviral immunity.Cell host & microbe,21(2),231-243.
MLA	Fu, Yu-Zhi,et al."Human cytomegalovirus tegument protein ul82 inhibits sting-mediated signaling to evade antiviral immunity".Cell host & microbe 21.2(2017):231-243.

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