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	Tracking single baculovirus retrograde transportation in host cell via quantum dot-labeling of virus internal component
	Wen, Li1,2; Zheng, Zhen-Hua3; Liu, An-An1,2; Lv, Cheng1,2; Zhang, Li-Juan1,2; Ao, Jian1,2; Zhang, Zhi-Ling1,2; Wang, Han-Zhong3; Lin, Yi1,2; Pang, Dai-Wen1,2,3
刊名	Journal of nanobiotechnology
	2017-05-06
卷号	15页码:10
关键词	Quantum dots Single virus tracking Baculovirus Retrograde transportation Host cells
ISSN号	1477-3155
DOI	10.1186/s12951-017-0270-9
通讯作者	Lin, yi(ylin@whu.edu.cn)
英文摘要	Background: quantum dot (qd)-based single virus tracking has become a powerful tool for dissecting virus infection mechanism. however, only virus behaviors at the early stage of retrograde trafficking have been dynamically tracked so far. monitoring of comprehensive virus retrograde transportation remains a challenge. results: based on the superior fluorescence properties of qds and their labeling of virus internal component, the dynamic interactions between baculoviruses and all key transportation-related cellular structures, including vesicles, acidic endosomes, actins, nuclear pores and nuclei, were visualized at the single-virus level. detailed scenarios and dynamic information were provided for these critical interaction processes. conclusions: a comprehensive model of baculovirus retrograde trafficking involving virus endocytosis, fusion with acidic endosome, translocation to nuclear periphery, internalization into nucleus, and arriving at the destination in nucleus was proposed. thus the whole retrograde transportation of baculovirus in live host cells was elucidated at the single-virus level for the first time.
WOS关键词	CLATHRIN-MEDIATED ENDOCYTOSIS ; INFLUENZA-VIRUS ; PARTICLE TRACKING ; NANOPARTICLES ; INFECTION ; ENVELOPE ; ENTRY
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS类目	Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
语种	英语
出版者	BIOMED CENTRAL LTD
WOS记录号	WOS:000402010100001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373439
专题	武汉病毒研究所
通讯作者	Lin, Yi
作者单位	1.Wuhan Univ, Key Lab Analyt Chem Biol & Med, Coll Chem & Mol Sci, Minist Educ,State Key Lab Virol,Inst Adv Studies, Wuhan 430072, Peoples R China 2.Wuhan Univ, Wuhan Inst Biotechnol, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Wen, Li,Zheng, Zhen-Hua,Liu, An-An,et al. Tracking single baculovirus retrograde transportation in host cell via quantum dot-labeling of virus internal component[J]. Journal of nanobiotechnology,2017,15:10.
APA	Wen, Li.,Zheng, Zhen-Hua.,Liu, An-An.,Lv, Cheng.,Zhang, Li-Juan.,...&Pang, Dai-Wen.(2017).Tracking single baculovirus retrograde transportation in host cell via quantum dot-labeling of virus internal component.Journal of nanobiotechnology,15,10.
MLA	Wen, Li,et al."Tracking single baculovirus retrograde transportation in host cell via quantum dot-labeling of virus internal component".Journal of nanobiotechnology 15(2017):10.

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