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	Novel bat adenoviruses with low g plus c content shed new light on the evolution of adenoviruses
	Tan, Bing1,2; Yang, Xing-Lou1; Ge, Xing-Yi1; Peng, Cheng1; Liu, Hai-Zhou1; Zhang, Yun-Zhi3; Zhang, Li-Biao4; Shi, Zheng-Li1,2
刊名	Journal of general virology
	2017-04-01
卷号	98期号:4页码:739-748
关键词	Bat adenovirus G plus c content Cpg methylation Base composition Genome length
ISSN号	0022-1317
DOI	10.1099/jgv.0.000739
通讯作者	Shi, zheng-li(zlshi@wh.iov.cn)
英文摘要	Bats have been reported to carry diverse adenoviruses. however, most bat adenoviruses have been identified on the basis of partial genome sequences, and knowledge on the evolution of bat adenoviruses remains limited. in this study, we isolated and characterized four novel adenoviruses from two distinct bat species, and their full-length genomes were sequenced. sequence analysis revealed that these isolates represented three distinct species of the genus mastadenovirus. however, all isolates had an exceptionally low g+c content and relatively short genomes compared with other known mastadenoviruses. we further analysed the relationships among the g+c content, 5'- c-phosphate- g-3' (cpg) representation and genome size in the family adenoviridae. our results revealed that the cpg representation in adenoviral genomes depends primarily on the level of methylation, and the genome size displayed significant positive correlations with both g+c content and cpg representation. since ancestral adenoviruses are believed to have contained short genomes, those probably had a low g+c content, similar to the genomes of these bat strains. our results suggest that bats are important natural reservoirs for adenoviruses and play important roles in the evolution of adenoviruses.
WOS关键词	GENETIC DIVERSITY ; GENOME ANALYSIS ; CODON USAGE ; DNA VIRUSES ; E3 GENES ; METHYLATION ; CHINA
WOS研究方向	Biotechnology & Applied Microbiology ; Virology
WOS类目	Biotechnology & Applied Microbiology ; Virology
语种	英语
出版者	MICROBIOLOGY SOC
WOS记录号	WOS:000401905000024
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373431
专题	武汉病毒研究所
通讯作者	Shi, Zheng-Li
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, Ctr Emerging Infect Dis, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Yunnan Inst Endem Dis Control & Prevent, Yunnan Prov Key Lab Zoonosis Control & Prevent, Dali, Peoples R China 4.Guangdong Inst Appl Biol Resource, Guangzhou, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Tan, Bing,Yang, Xing-Lou,Ge, Xing-Yi,et al. Novel bat adenoviruses with low g plus c content shed new light on the evolution of adenoviruses[J]. Journal of general virology,2017,98(4):739-748.
APA	Tan, Bing.,Yang, Xing-Lou.,Ge, Xing-Yi.,Peng, Cheng.,Liu, Hai-Zhou.,...&Shi, Zheng-Li.(2017).Novel bat adenoviruses with low g plus c content shed new light on the evolution of adenoviruses.Journal of general virology,98(4),739-748.
MLA	Tan, Bing,et al."Novel bat adenoviruses with low g plus c content shed new light on the evolution of adenoviruses".Journal of general virology 98.4(2017):739-748.

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