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	Resveratrol reactivates latent hiv through increasing histone acetylation and activating heat shock factor 1
	Zeng, Xiaoyun1; Pan, Xiaoyan1,2; Xu, Xinfeng1; Lin, Jian1; Que, Fuchang1; Tian, Yuanxin1; Li, Lin1; Liu, Shuwen1,3
刊名	Journal of agricultural and food chemistry
	2017-06-07
卷号	65期号:22页码:4384-4394
关键词	Resveratrol Latent hiv Histone acetylation Heat shock factor 1 Synergistic reactivation
ISSN号	0021-8561
DOI	10.1027/acs.jafc.7b00418
通讯作者	Liu, shuwen(liusw@smu.edu.cn)
英文摘要	The persistence of latent hiv reservoirs presents a significant challenge to viral eradication. effective latency reversing agents (lras) based on "shock and kill" strategy are urgently needed. the natural phytoalexin resveratrol has been demonstrated to enhance hiv gene expression, although its mechanism remains unclear. in this study, we demonstrated that resveratrol was able to reactivate latent hiv without global t cell activation in vitro. mode of action studies showed resveratrol-mediated reactivation from latency did not involve the activation of silent mating type information regulation 2 homologue 1 (sirt1), which belonged to class-3 histone deacetylase (hdac). however, latent hiv was reactivated by resveratrol mediated through increasing histone acetylation and activation of heat shock factor 1 (hsf1). additionally, synergistic activation of the latent hiv reservoirs was observed under cotreatment with resveratrol and conventional lras. collectively, this research reveals that resveratrol is a natural lra and shows promise for hiv therapy.
WOS关键词	HUMAN-IMMUNODEFICIENCY-VIRUS ; CELL-CYCLE PROGRESSION ; T-CELLS ; TRANSCRIPTIONAL ELONGATION ; SYNERGISTIC INHIBITION ; ANTIRETROVIRAL THERAPY ; BLOOD-LYMPHOCYTES ; IN-VITRO ; P-TEFB ; INFECTION
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
WOS类目	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000403136600003
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373427
专题	武汉病毒研究所
通讯作者	Liu, Shuwen
作者单位	1.Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Guangzhou 510515, Guangdong, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 3.Southern Med Univ, Guangdong Prov Inst Nephrol, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zeng, Xiaoyun,Pan, Xiaoyan,Xu, Xinfeng,et al. Resveratrol reactivates latent hiv through increasing histone acetylation and activating heat shock factor 1[J]. Journal of agricultural and food chemistry,2017,65(22):4384-4394.
APA	Zeng, Xiaoyun.,Pan, Xiaoyan.,Xu, Xinfeng.,Lin, Jian.,Que, Fuchang.,...&Liu, Shuwen.(2017).Resveratrol reactivates latent hiv through increasing histone acetylation and activating heat shock factor 1.Journal of agricultural and food chemistry,65(22),4384-4394.
MLA	Zeng, Xiaoyun,et al."Resveratrol reactivates latent hiv through increasing histone acetylation and activating heat shock factor 1".Journal of agricultural and food chemistry 65.22(2017):4384-4394.

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