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	Human cytomegalovirus infection dysregulates neural progenitor cell fate by disrupting hes1 rhythm and down-regulating its expression
	Liu, Xi-Juan1,2; Jiang, Xuan1,3; Huang, Sheng-Nan1; Sun, Jin-Yan1; Zhao, Fei1; Zeng, Wen-Bo1; Luo, Min-Hua1
刊名	Virologica sinica
	2017-06-01
卷号	32期号:3页码:188-198
关键词	Human cytomegalovirus (hcmv) Neural progenitor cells (npcs) Hes1 rhythm Cell fate
ISSN号	1674-0769
DOI	10.1007/s12250-017-3956-0
通讯作者	Zeng, wen-bo(zengwb@wh.iov.cn) ; Luo, min-hua(luomh@wh.iov.cn)
英文摘要	Human cytomegalovirus (hcmv) infection is a leading cause of birth defects, primarily affecting the central nervous system and causing its maldevelopment. as the essential downstream effector of notch signaling pathway, hes1, and its dynamic expression, plays an essential role on maintaining neural progenitor /stem cells (npcs) cell fate and fetal brain development. in the present study, we reported the first observation of hes1 oscillatory expression in human npcs, with an approximately 1.5 hour periodicity and a hes1 protein half-life of about 17 (17.6 +/- 0.2) minutes. hcmv infection disrupts the hes1 rhythm and down-regulates its expression. furthermore, we discovered that depleting hes1 protein disturbed npcs cell fate by suppressing npcs proliferation and neurosphere formation, and driving npcs abnormal differentiation. these results suggested a novel mechanism linking disruption of hes1 rhythm and down-regulation of hes1 expression to neurodevelopmental disorders caused by congenital hcmv infection.
WOS关键词	STEM-CELLS ; SIGNALING PROTEIN ; MAMMALIAN HAIRY ; NERVOUS-SYSTEM ; HEARING-LOSS ; GENES ; NOTCH ; DIFFERENTIATION ; LOOP ; NEUROGENESIS
WOS研究方向	Virology
WOS类目	Virology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000404713800002
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373416
专题	武汉病毒研究所
通讯作者	Zeng, Wen-Bo; Luo, Min-Hua
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, CAS Ctr Excellence Brain Sci & Intelligence Techn, State Key Lab Virol, Wuhan 430071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Guangzhou Women & Children Med Ctr, Guangzhou Inst Pediat, Joint Ctr Translat Precis Med, Guangzhou 510000, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xi-Juan,Jiang, Xuan,Huang, Sheng-Nan,et al. Human cytomegalovirus infection dysregulates neural progenitor cell fate by disrupting hes1 rhythm and down-regulating its expression[J]. Virologica sinica,2017,32(3):188-198.
APA	Liu, Xi-Juan.,Jiang, Xuan.,Huang, Sheng-Nan.,Sun, Jin-Yan.,Zhao, Fei.,...&Luo, Min-Hua.(2017).Human cytomegalovirus infection dysregulates neural progenitor cell fate by disrupting hes1 rhythm and down-regulating its expression.Virologica sinica,32(3),188-198.
MLA	Liu, Xi-Juan,et al."Human cytomegalovirus infection dysregulates neural progenitor cell fate by disrupting hes1 rhythm and down-regulating its expression".Virologica sinica 32.3(2017):188-198.

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