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	Role of hdac9-foxo1 axis in the transcriptional program associated with hepatic gluconeogenesis
	Chen, Jizheng2; Zhang, Zhilei1; Wang, Ning1; Guo, Min3; Chi, Xiumei4; Pan, Yu4; Jiang, Jing4; Niu, Junqi4; Ksimu, Sulaiman5; Li, John Zhong1
刊名	Scientific reports
	2017-07-21
卷号	7页码:12
ISSN号	2045-2322
DOI	10.1038/s41598-017-06328-3
通讯作者	Wang, qian(wqian@njmu.edu.cn)
英文摘要	Histone deacetylase 9 (hdac9) regulates hepatic gluconeogenesis by deacetylating forkhead box o 1 (foxo1). hdac9 upregulation is involved in hepatitis c virus (hcv)-associated exaggerated gluconeogenesis. herein, we found in addition to foxo1, hdac9 also regulates other gluconeogenic transcription factors, including peroxisomeproliferator-activated receptor-gamma coactivator-1a (pgc-1a), cyclic amp-responsive element-binding protein (creb), and glucocorticoid receptor (gr). unlike foxo1, which is regulated by post-translational modification responses to hdac9, hdac9 regulates pgc-1a, creb and gr by altering gene expression. similar to pgc-1a, creb and gr were found to be novel regulatory targets of foxo1 by examination of the foxo1 binding site in their promoter. pgc-1a, creb and gr were upregulated in response to hdac9 via foxo1 deacetylation. these findings indicate that hdac9-foxo1 signalling contributes to gluconeogenesis by modulating the expression of gluconeogenic transcription factors. in particular, metabolic profiling demonstrated a clear shift towards gluconeogenesis metabolism, and hdac9-foxo1 signalling can be strongly induced to upregulate gluconeogenic transcription factors following hcv infection. the positive correlation between hdac9 and gluconeogenic transcription factor expression levels in the livers of both hcvinfected patients and normal individuals further emphasizes the clinical relevance of these results. thus, hdac9-foxo1 signalling axis is involved in regulating gluconeogenic transcription factors, gluconeogenesis, and hcv-induced type 2 diabetes.
WOS关键词	C VIRUS-INFECTION ; GLUCOSE-HOMEOSTASIS ; INSULIN-RESISTANCE ; ENERGY-METABOLISM ; COACTIVATOR PGC-1 ; PGC-1-ALPHA ; RECEPTOR ; LIVER ; REGULATOR ; CREB
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000406285700010
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373370
专题	武汉病毒研究所
通讯作者	Wang, Qian
作者单位	1.Nanjing Med Univ, Dept Biochem & Mol Biol, Jiangsu Prov Key Lab Human Funct Genom, Nanjing 210029, Jiangsu, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 3.China Pharmaceut Univ, Sch Life Sci & Technol, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China 4.Jilin Univ, Dept Hepatol, Hosp 1, Changchun 130021, Jilin, Peoples R China 5.Xinjiang Med Univ, Affiliated Hosp 1, Ctr Technol & Educ, Urumqi 830054, Peoples R China
推荐引用方式 GB/T 7714	Chen, Jizheng,Zhang, Zhilei,Wang, Ning,et al. Role of hdac9-foxo1 axis in the transcriptional program associated with hepatic gluconeogenesis[J]. Scientific reports,2017,7:12.
APA	Chen, Jizheng.,Zhang, Zhilei.,Wang, Ning.,Guo, Min.,Chi, Xiumei.,...&Wang, Qian.(2017).Role of hdac9-foxo1 axis in the transcriptional program associated with hepatic gluconeogenesis.Scientific reports,7,12.
MLA	Chen, Jizheng,et al."Role of hdac9-foxo1 axis in the transcriptional program associated with hepatic gluconeogenesis".Scientific reports 7(2017):12.

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