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	Heat shock factor 1 suppresses the hiv-induced inflammatory response by inhibiting nuclear factor-kappa b
	Pan, Xiaoyan1,2; Lin, Jian2; Zeng, Xiaoyun2; Li, Wenjuan2; Wu, Wenjiao2,4; Lu, Wan Zhen2; Liu, Jing4; Liu, Shuwen2,3
刊名	Cellular immunology
	2018-05-01
卷号	327页码:26-35
关键词	Inflammation Hiv Heat shock factor 1 Nuclear factor-kappa b Host restrictive factor
ISSN号	0008-8749
DOI	10.1016/j.cellimm.2018.01.015
通讯作者	Liu, shuwen(liusw@smu.edu.cn)
英文摘要	The persistent inflammation aggravated by a disordered immune response is considered to be the major cause of cd4(+) t cell depletion in lymphoid tissue, which impels the progression of aids. here, we report that heat shock factor 1 (hsf1) works as an innate repressor of hiv-induced inflammation. the activation of hsf1 was found to accompany inflammation during hiv infection. further research uncovered that hsf1 activation inhibited hiv-induced inflammation. in addition, hsf1 overexpression suppressed the inflammatory response induced by hiv, while hsf1 deficiency exacerbated that inflammation. mechanistically, hsf1 was found to compete with nuclear factor-kappa b (nf-kappa b) in the nucleus. generally, our report highlights that hsf1 is an important host factor in regulating hiv-induced inflammation and may work as a potential target for curing aids.
WOS关键词	CD4 T-CELLS ; LATENT HIV ; INFECTION ; TRANSCRIPTION ; ACTIVATION ; INTERLEUKIN-6 ; PERSPECTIVES ; PATHOGENESIS ; REACTIVATION ; METABOLISM
WOS研究方向	Cell Biology ; Immunology
WOS类目	Cell Biology ; Immunology
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000429751900004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373329
专题	武汉病毒研究所
通讯作者	Liu, Shuwen
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Southern Med Univ, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Sch Pharmaceut Sci, Guangdong Prov Key Lab Drug Screening, Guangzhou 510515, Guangdong, Peoples R China 3.Southern Med Univ, Guangdong Prov Inst Nephrol, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China 4.Northwestern Univ, Div Pulm & Crit Care Med, Feinberg Sch Med, Chicago, IL 60611 USA
推荐引用方式 GB/T 7714	Pan, Xiaoyan,Lin, Jian,Zeng, Xiaoyun,et al. Heat shock factor 1 suppresses the hiv-induced inflammatory response by inhibiting nuclear factor-kappa b[J]. Cellular immunology,2018,327:26-35.
APA	Pan, Xiaoyan.,Lin, Jian.,Zeng, Xiaoyun.,Li, Wenjuan.,Wu, Wenjiao.,...&Liu, Shuwen.(2018).Heat shock factor 1 suppresses the hiv-induced inflammatory response by inhibiting nuclear factor-kappa b.Cellular immunology,327,26-35.
MLA	Pan, Xiaoyan,et al."Heat shock factor 1 suppresses the hiv-induced inflammatory response by inhibiting nuclear factor-kappa b".Cellular immunology 327(2018):26-35.

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