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	Mir-16-5p mediates a positive feedback loop in ev71-induced apoptosis and suppresses virus replication
	Zheng, Caishang1,2; Zheng, Zhenhua2; Sun, Jianhong2; Zhang, Yuan2; Wei, Chunyu2; Ke, Xianliang1,2; Liu, Yan2; Deng, Li1; Wang, Hanzhong2
刊名	Scientific reports
	2017-11-27
卷号	7页码:16
ISSN号	2045-2322
DOI	10.1038/s41598-017-16616-7
通讯作者	Zheng, zhenhua(zhengzh@wh.iov.cn) ; Deng, li(drdengli@126.com)
英文摘要	Enterovirus 71 (ev71) is the predominant causative pathogen of hand-foot-and-mouth disease (hfmd). contrary to other hfmd-causing enterovirus, ev71 can lead to severe neurological complications, even death. micrornas (mirnas) are small non-coding rnas that constitute the largest family of gene regulators participating in numerous biological or pathological processes. we previously reported that mir-16-5p increases with severity of hfmd by investigating the expression patterns of host mirnas in patients with hfmd. however, the mechanisms by which ev71 induces mir-16-5p expression are not clear, and the interaction between ev71 and mir-16-5p is not yet fully understood. here, we confirmed ev71-induced expression of mir-16-5p both in vitro and in vivo and show that upregulation of mir-16-5p by ev71 infection may occur at the posttranscriptional level. moreover, ev71-induced caspase activation facilitates the processing of pri-mir-16-1. we also revealed that mir-16-5p can promote ev71-induced nerve cells apoptosis through activating caspase-3. in addition, we found that mir-16-5p can inhibit ev71 replication. ccne1 and ccnd1, two important cell cycle regulators, play an important role in the suppression of ev71 replication by mir-16-5p. therefore, mir-16-5p is a positive feedback regulator in ev71-induced apoptosis and a suppressor of virus replication. these results help in understanding the interaction network between mirna and ev71 infection and provide a potential target for the development of antiviral therapy.
WOS关键词	ENTEROVIRUS 71 REPLICATION ; MOUTH-DISEASE ; RNA INTERFERENCE ; VIRAL-INFECTION ; MICRORNA BIOGENESIS ; CLINICAL-FEATURES ; WESTERN-AUSTRALIA ; HAND ; FOOT ; COMPLEX
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000416308200030
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373308
专题	武汉病毒研究所
通讯作者	Zheng, Zhenhua; Deng, Li
作者单位	1.Guangzhou Women & Children Med Ctr, Guangzhou Inst Pediat, Guangzhou 510623, Guangdong, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Caishang,Zheng, Zhenhua,Sun, Jianhong,et al. Mir-16-5p mediates a positive feedback loop in ev71-induced apoptosis and suppresses virus replication[J]. Scientific reports,2017,7:16.
APA	Zheng, Caishang.,Zheng, Zhenhua.,Sun, Jianhong.,Zhang, Yuan.,Wei, Chunyu.,...&Wang, Hanzhong.(2017).Mir-16-5p mediates a positive feedback loop in ev71-induced apoptosis and suppresses virus replication.Scientific reports,7,16.
MLA	Zheng, Caishang,et al."Mir-16-5p mediates a positive feedback loop in ev71-induced apoptosis and suppresses virus replication".Scientific reports 7(2017):16.

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