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	Effect of nitroprusside (nitric-oxide) on endogenous dopamine release from rat striatal slices
	ZHU, XZ; LUO, LG
刊名	Journal of neurochemistry
	1992-09-01
卷号	59期号:3页码:932-935
关键词	Nitric oxide Dopamine release Striatum
ISSN号	0022-3042
通讯作者	Zhu, xz()
英文摘要	It is becoming apparent that the synthesis of nitric oxide (no) from l-arginine not only explains endothelium-dependent vascular relaxation, but is a widespread mechanism for the regulation of cell function and communication. we examined the role of no on the endogenous dopamine (da) release from rat striatum. nitroprusside, in the concentration range of 3-100-mu-m, induced a dose-dependent increase in the endogenous da release from rat striatal slices. the maximal response was 330% over the baseline release. a higher concentration of nitroprusside (300-mu-m) produced an inhibitory effect on the spontaneous release of da. l-arginine (10 and 100-mu-m), a substrate in the no-forming enzyme system, also produced an elevation of da release. l-arginine-induced da release was attenuated by n(g)-monomethyl-l-arginine, an inhibitor of no synthase. nadph (1-mu-m), a cofactor of no synthase, enhanced l-arginine-induced da release. these results suggest a possible involvement of no in the da release process in rat striatum.
WOS关键词	NERVOUS-SYSTEM ; L-ARGININE ; BRAIN ; ACTIVATION ; MESSENGER ; CATECHOLAMINES ; GLUTAMATE ; CELLS
WOS研究方向	Biochemistry & Molecular Biology ; Neurosciences & Neurology
WOS类目	Biochemistry & Molecular Biology ; Neurosciences
语种	英语
出版者	LIPPINCOTT-RAVEN PUBL
WOS记录号	WOS:A1992JJ44200016
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373291
专题	武汉病毒研究所
通讯作者	ZHU, XZ
作者单位	CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL,319 YUE YANG RD,SHANGHAI 200031,PEOPLES R CHINA
推荐引用方式 GB/T 7714	ZHU, XZ,LUO, LG. Effect of nitroprusside (nitric-oxide) on endogenous dopamine release from rat striatal slices[J]. Journal of neurochemistry,1992,59(3):932-935.
APA	ZHU, XZ,&LUO, LG.(1992).Effect of nitroprusside (nitric-oxide) on endogenous dopamine release from rat striatal slices.Journal of neurochemistry,59(3),932-935.
MLA	ZHU, XZ,et al."Effect of nitroprusside (nitric-oxide) on endogenous dopamine release from rat striatal slices".Journal of neurochemistry 59.3(1992):932-935.

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