| Surveillance of hiv-1 drug resistance in xinjiang: high prevalence of k103n in treatment-naive individuals | |
| Shu, Zhanjun1,4; Chen, Yuying2,3; Abudureyimu, Aihemaiti1; Li, Tingting2,3; Yuan, Ting2; Ma, Jianping1; Li, Xiaochun4; Ma, Xiulan1; Jang, Chengyuan4; Bao, Gang4 | |
| 刊名 | Archives of virology
 |
| 2018-08-01 | |
| 卷号 | 163期号:8页码:2111-2119 |
| ISSN号 | 0304-8608 |
| DOI | 10.1007/s00705-018-3825-7 |
| 通讯作者 | Sun, binlian(binlian17@jhun.edu.cn) ; Yang, rongge(ryang@wh.iov.cn) |
| 英文摘要 | To identify transmitted and acquired hiv-1 drug resistance mutations in xinjiang, china, we collected the peripheral blood of 50 treated and 50 treatment-naive hiv-1-infected individuals in this region. we successfully amplified 36 reverse transcriptase and 42 protease gene sequences of hiv-1 from 51 individuals and identified mutations associated with resistance to reverse transcriptase (rt) and protease (pr) inhibitors (rtis and pis) according to stanford drug resistance database. among the drug-treated individuals, the results showed that k103n in the rt region was the most frequent mutation, found in 67% (6/9) of the cases, followed by m184v with 56% (5/9). five individuals had both nucleoside and non-nucleoside reverse transcriptase inhibitor resistance mutations after more than 12 months of treatment. among the untreated individuals, 33% (9/27) were found to harbor drug resistance mutations in the rt gene. k103n occurred at the highest rate, accounting for 22% (6/27), followed by p225h (7%) and y188l (4%). neither of the two groups showed any major resistance mutations to pis. our study revealed that the prevalence of drug resistance was relatively high in xinjiang and that k103n occurred at the highest rate. these results suggest that it is important to carry out hiv drug resistance testing, especially for the k103n mutation in the rt region, before and during the treatment process. this study may help to guide art strategies in the xinjiang region. |
| WOS关键词 | SUB-SAHARAN AFRICA ; ANTIRETROVIRAL THERAPY ; CHINA ; MUTATIONS ; RATES |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| 出版者 | SPRINGER WIEN |
| WOS记录号 | WOS:000440727000014 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2373251 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Sun, Binlian; Yang, Rongge |
| 作者单位 | 1.Xinjiang Med Univ, Affiliated Hosp 4, Urumqi, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Res Grp HIV Mol Epidemiol & Virol 1, Wuhan 430071, Hubei, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Sixth Peoples Hosp Xinjiang Uygur Autonomous Reg, Urumqi, Peoples R China 5.Jianghan Univ, Sch Med, Wuhan 430056, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shu, Zhanjun,Chen, Yuying,Abudureyimu, Aihemaiti,et al. Surveillance of hiv-1 drug resistance in xinjiang: high prevalence of k103n in treatment-naive individuals[J]. Archives of virology,2018,163(8):2111-2119. |
| APA | Shu, Zhanjun.,Chen, Yuying.,Abudureyimu, Aihemaiti.,Li, Tingting.,Yuan, Ting.,...&Yang, Rongge.(2018).Surveillance of hiv-1 drug resistance in xinjiang: high prevalence of k103n in treatment-naive individuals.Archives of virology,163(8),2111-2119. |
| MLA | Shu, Zhanjun,et al."Surveillance of hiv-1 drug resistance in xinjiang: high prevalence of k103n in treatment-naive individuals".Archives of virology 163.8(2018):2111-2119. |
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