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	Opposite effects of drosophila c3po on gene silencing mediated by esi-2.1 and mirna-bantam
	Liu, Yujie1; Fang, Yuan1,2; Liu, Yongxiang1,2; Wang, Zhaowei1,2; Lyu, Bao1; Hu, Yuanyang1; Zhou, Xi1,2
刊名	Acta biochimica et biophysica sinica
	2019-02-01
卷号	51期号:2页码:131-138
关键词	C3po Translin Trax Esi-2,1 Mir-bantam
ISSN号	1672-9145
DOI	10.1093/abbs/gmy154
通讯作者	Zhou, xi(zhouxi@wh.iov.cn)
英文摘要	Translin/trax complex, also named as c3po, is evolutionarily conserved and participates in diverse cellular processes in different organisms from yeast to human. c3po plays a critical role in the activation of rna-induced silencing complexes by promoting the unwinding and degradation of passenger strand of exogenous sirnas (exo-sirnas) in drosophila and human. moreover, human c3po (hc3po) has been found to broadly repress mirnas by degrading mirna precursors. however, the effect of drosophila melanogaster c3po (dmc3po) on endogenous sirna (endo-sirna) and mirna pathways remains unknown. here, we found that the loss of dmc3po promoted the accumulation of the passenger strand of esi-2.1 (hp-cg4068b), and resulted in the de-repression of the dna-damage-response gene mutagensensitive 308 (mus308), which is an endogenous slicer target of esi-2.1 in drosophila. moreover, we also found that depletion of dmc3po increased the accumulation of mir-bantam. taken together, our findings indicated that dmc3po not only involves in sirna pathway triggered by dsrna, but also regulates the abundance of certain endogenous small rnas in drosophila.
WOS关键词	DISTINCT MECHANISMS ; ENDOGENOUS SIRNAS ; RNA INTERFERENCE ; TRANSLIN ; PROTEIN ; PATHWAY ; SUPPRESSION ; INHIBITION ; INFECTION ; CLEAVAGE
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000462569900002
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373166
专题	武汉病毒研究所
通讯作者	Zhou, Xi
作者单位	1.Wuhan Univ, State Key Lab Virol, Coll Life Sci, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yujie,Fang, Yuan,Liu, Yongxiang,et al. Opposite effects of drosophila c3po on gene silencing mediated by esi-2.1 and mirna-bantam[J]. Acta biochimica et biophysica sinica,2019,51(2):131-138.
APA	Liu, Yujie.,Fang, Yuan.,Liu, Yongxiang.,Wang, Zhaowei.,Lyu, Bao.,...&Zhou, Xi.(2019).Opposite effects of drosophila c3po on gene silencing mediated by esi-2.1 and mirna-bantam.Acta biochimica et biophysica sinica,51(2),131-138.
MLA	Liu, Yujie,et al."Opposite effects of drosophila c3po on gene silencing mediated by esi-2.1 and mirna-bantam".Acta biochimica et biophysica sinica 51.2(2019):131-138.

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