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	Hplc with cellulose tris (3,5-dimethylphenylcarbamate) chiral stationary phase: influence of coating times and coating amount on chiral discrimination
	Wei, Qiuhong1,2; Su, Hongjiu1; Gao, Diannan1; Wang, Shudong1
刊名	Chirality
	2019-03-01
卷号	31期号:3页码:164-173
关键词	Cellulose tris (3,5-dimethylphenylcarbamate) Chiral recognition Chiral stationary phase Enantioseparation High-performance liquid chromatography Resolution
ISSN号	0899-0042
DOI	10.1002/chir.23044
通讯作者	Su, hongjiu(suhj@dicp.ac.cn) ; Wang, shudong(wangsd@dicp.ac.cn)
英文摘要	Coating cellulose tris (3,5-dimethylphenylcarbamate) (cdmpc) on silica gels with large pores have been demonstrated as an efficient way for the preparation of chiral stationary phase (csp) for high-performance liquid chromatography (hplc). during the process, a number of parameters, including the type of coating solvent, amount of coating, and the method for subsequent solvent removing, have been proved to affect the performance of the resultant csps. coating times and the concentration of coating solution, however, also makes a difference to csps' performance by changing the arrangement of cellulose derivatives while remaining the coating amount constant, have much less been studied before, and thereby, were systematically investigated in this work. results showed that csps with more coating times exhibited higher chiral recognition and column efficiency, suggesting that resolution was determined by column efficiency herein. afterwards, we also investigated the effect of coating amount on the performance of csps, and it was shown that the ability of enantio-recognition did not increase all the time as the coating amount; and four of seven racemates achieved best resolution when the coating amount reached to 18.37%. at the end, the reproducibility of cdmpc-coated csps were further confirmed by two methods, ie, reprepared the csp-0.15-3 and reevaluated the effect of coating times.
WOS关键词	PERFORMANCE LIQUID-CHROMATOGRAPHY ; SILICA-GEL ; RESOLUTION ; ENANTIOMERS ; SEPARATION ; TRIS(3,5-DIMETHYLPHENYLCARBAMATE) ; ENANTIOSEPARATION ; DERIVATIVES
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
WOS类目	Chemistry, Medicinal ; Chemistry, Analytical ; Chemistry, Organic ; Pharmacology & Pharmacy
语种	英语
出版者	WILEY
WOS记录号	WOS:000458827600002
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2372777
专题	大连化学物理研究所
通讯作者	Su, Hongjiu; Wang, Shudong
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, 457 Zhongshan Rd, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wei, Qiuhong,Su, Hongjiu,Gao, Diannan,et al. Hplc with cellulose tris (3,5-dimethylphenylcarbamate) chiral stationary phase: influence of coating times and coating amount on chiral discrimination[J]. Chirality,2019,31(3):164-173.
APA	Wei, Qiuhong,Su, Hongjiu,Gao, Diannan,&Wang, Shudong.(2019).Hplc with cellulose tris (3,5-dimethylphenylcarbamate) chiral stationary phase: influence of coating times and coating amount on chiral discrimination.Chirality,31(3),164-173.
MLA	Wei, Qiuhong,et al."Hplc with cellulose tris (3,5-dimethylphenylcarbamate) chiral stationary phase: influence of coating times and coating amount on chiral discrimination".Chirality 31.3(2019):164-173.

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