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	Preparation of epoxy-functionalized hierarchically porous hybrid monoliths via free radical polymerization and application in hilic enrichment of glycopeptides
	Ma, Shujuan1,2; Zhang, Luwei1,2; Wang, Shuyue2; Zhang, Haiyang1,2; You, Xin2,3; Ou, Junjie2; Ye, Mingliang2; Wei, Yinmao1
刊名	Analytica chimica acta
	2019-06-13
卷号	1058页码:97-106
关键词	Hierarchically porous material Hybrid monolith Polyhedral oligomeric silsesquioxanes Hydrophilic interaction chromatography Glycopeptides enrichment
ISSN号	0003-2670
DOI	10.1016/j.aca.2019.01.011
通讯作者	Wei, yinmao(ymwei@nwu.edu.cn)
英文摘要	Owing to their multiscale pore size regimes and unique properties, the materials with hierarchically porous structures have become an important family of functional materials in recent years. they have been applied from energy conversion and storage, catalysis, separation to drug delivery, etc. the synthesis of them is difficult by the need to employ multiple templates and take complicated steps. herein, we successfully prepared epoxy-functionalized hierarchically porous hybrid monoliths (hphms) with micro/meso/macro-structures in an easy way. firstly, a bulk monolithic material was formed via free radical polymerization between polyhedral oligomeric vinylsilsesquioxanes (vinylposs) and allyl glycidyl ether (age) in the presence of polycaprolactone (pcl). then pcl was degraded with hydrochloric acid solution, and the epoxy-functionalized hphm was obtained. this approach was very simple and suitable for large-scale preparation. hybrid monoliths with different specific surface area (from 5.4 to 636.7 m(2)/g) were prepared by adjusting the mole ratio of vinylposs to age and the content of pcl. the results of several characterization methods, including nitrogen adsorption/desorption measurements, scanning electron microscopy (sem) and mercury intrusion porosimetry (mip), showed that these materials contained not only micropores and mesopores but also macropores. the materials were further modified with penicillamine to be used as hydrophilic interaction chromatography (hilic) adsorbents for enriching n-glycopeptides in igg and serum protein tryptic digests. up to 23 n-glycopeptides were identified from igg digest, and 385 n-glycopeptides and 283 n-glycosylation sites were identified from human serum digest. (c) 2019 elsevier b.v. all rights reserved.
WOS关键词	HIGHLY SPECIFIC ENRICHMENT ; SELECTIVE ENRICHMENT ; MASS-SPECTROMETRY ; IDENTIFICATION ; GLYCOSYLATION ; EFFICIENT ; GLYCOPROTEOMICS ; SEPARATION ; DESIGN ; MATRIX
WOS研究方向	Chemistry
WOS类目	Chemistry, Analytical
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000460376500011
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2372723
专题	大连化学物理研究所
通讯作者	Wei, Yinmao
作者单位	1.Northwest Univ, Coll Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Shaanxi, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Ma, Shujuan,Zhang, Luwei,Wang, Shuyue,et al. Preparation of epoxy-functionalized hierarchically porous hybrid monoliths via free radical polymerization and application in hilic enrichment of glycopeptides[J]. Analytica chimica acta,2019,1058:97-106.
APA	Ma, Shujuan.,Zhang, Luwei.,Wang, Shuyue.,Zhang, Haiyang.,You, Xin.,...&Wei, Yinmao.(2019).Preparation of epoxy-functionalized hierarchically porous hybrid monoliths via free radical polymerization and application in hilic enrichment of glycopeptides.Analytica chimica acta,1058,97-106.
MLA	Ma, Shujuan,et al."Preparation of epoxy-functionalized hierarchically porous hybrid monoliths via free radical polymerization and application in hilic enrichment of glycopeptides".Analytica chimica acta 1058(2019):97-106.

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