Cadinane Sesquiterpenes from the brown alga Dictyopteris divaricata

doi:10.1021/np404499d

	Cadinane Sesquiterpenes from the brown alga Dictyopteris divaricata
	Song, FH ; Fan, X ; Xu, XL ; Zhao, JL ; Yang, YC ; Shi, JG ; Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
刊名	JOURNAL OF NATURAL PRODUCTS
	2004-10-01
卷号	67 期号:10 页码:1644-1649
关键词	Germacrane-type Sesquiterpene Rhodomela-confervoides Marine Plants Benzoic-acid Constituents Zonarioides Hydrocarbons Derivatives
ISSN号	0163-3864
DOI	10.1021/np404499d
文献子类	Article
英文摘要	Seven new cadinane sesquiterpenes, (-)-(1R,6S,7S,10R)-1-hydroxycadinan-3-en-5-one (1), (+)-(1R,5S,6R,7S, 10R)-cadinan-3-ene-1,5-diol (2), (+)-(1R,5R,6R,7S,10R)-cadinan-3-ene-1,5-diol (3), (+)-(1R,5S,6R,7S,10R)-cadinan-4(11)-ene-1,5-diol (4), (+)-(1R,5R,6R,7R,10R)-cadinan-4(11)-ene-1,5,12-triol (5), (-)-(1R,4R,5S,6R,7S, 10R)-cadinan-1,4,5-triol (6), and (-)-(1R,6R,7S,10R)-11-oxocadinan-4-en-1-ol (7), together with nine known compounds were isolated from the brown alga Dictyopteris divaricata. The structures of the new natural products, as well as their absolute configuration, were established by means of spectroscopic data including IR, HRMS, 1D and 2D NMR, single-crystal X-ray diffraction, and CD. All compounds were inactive against several human cancer cell lines including lung adenocarcinoma (A549), stomach cancer (BGC-823), breast cancer (MCF-7), hepatoma (Bel7402), and colon cancer (HCT-8) cell lines.; Seven new cadinane sesquiterpenes, (-)-(1R,6S,7S,10R)-1-hydroxycadinan-3-en-5-one (1), (+)-(1R,5S,6R,7S, 10R)-cadinan-3-ene-1,5-diol (2), (+)-(1R,5R,6R,7S,10R)-cadinan-3-ene-1,5-diol (3), (+)-(1R,5S,6R,7S,10R)-cadinan-4(11)-ene-1,5-diol (4), (+)-(1R,5R,6R,7R,10R)-cadinan-4(11)-ene-1,5,12-triol (5), (-)-(1R,4R,5S,6R,7S, 10R)-cadinan-1,4,5-triol (6), and (-)-(1R,6R,7S,10R)-11-oxocadinan-4-en-1-ol (7), together with nine known compounds were isolated from the brown alga Dictyopteris divaricata. The structures of the new natural products, as well as their absolute configuration, were established by means of spectroscopic data including IR, HRMS, 1D and 2D NMR, single-crystal X-ray diffraction, and CD. All compounds were inactive against several human cancer cell lines including lung adenocarcinoma (A549), stomach cancer (BGC-823), breast cancer (MCF-7), hepatoma (Bel7402), and colon cancer (HCT-8) cell lines.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
URL标识	查看原文
语种	英语
WOS记录号	WOS:000224707700002
公开日期	2010-11-18
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/1875]
专题	海洋研究所_海洋生物技术研发中心
通讯作者	Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
作者单位	1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 2.Peking Union Med Coll, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Song, FH,Fan, X,Xu, XL,et al. Cadinane Sesquiterpenes from the brown alga Dictyopteris divaricata[J]. JOURNAL OF NATURAL PRODUCTS,2004,67(10):1644-1649.
APA	Song, FH.,Fan, X.,Xu, XL.,Zhao, JL.,Yang, YC.,...&Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China.(2004).Cadinane Sesquiterpenes from the brown alga Dictyopteris divaricata.JOURNAL OF NATURAL PRODUCTS,67(10),1644-1649.
MLA	Song, FH,et al."Cadinane Sesquiterpenes from the brown alga Dictyopteris divaricata".JOURNAL OF NATURAL PRODUCTS 67.10(2004):1644-1649.