Comparative expression analysis of transcription factor genes in the endostyle of invertebrate chordates

doi:10.1002/dvdy.20401

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	Comparative expression analysis of transcription factor genes in the endostyle of invertebrate chordates
	Hiruta, J ; Mazet, F ; Yasui, K ; Zhang, PJ ; Ogasawara, M ; Ogasawara, M, Chiba Univ, Fac Sci, Dept Biol, Chiba 2638522, Japan
刊名	DEVELOPMENTAL DYNAMICS
	2005-07-01
卷号	233 期号:3 页码:1031-1037
关键词	Comparative Expression Analysis Endostyle Thyroid Evolution Ascidian Amphioxus
ISSN号	1058-8388
DOI	10.1002/dvdy.20401
文献子类	Article
英文摘要	The endostyle of invertebrate chordates is a pharyngeal organ that is thought to be homologous with the follicular thyroid of vertebrates. Although thyroid-like features such as iodine-concentrating and peroxidase activities are located in the dorsolateral part of both ascidian and amphioxus endostyles, the structural organization and numbers of functional units are different. To estimate phylogenetic relationships of each functional zone with special reference to the evolution of the thyroid, we have investigated, in ascidian and amphioxus, the expression patterns of thyroid-related transcription factors such as TTF-2/MoxE4 and Pax2/5/8, as well as the forkhead transcription factors FoxQ1 and FoxA. Comparative gene expression analyses depicted an overall similarity between ascidians and amphioxus endostyles, while differences in expression patterns of these genes might be specifically related to the addition or elimination of a pair of glandular zones. Expressions of Ci-FoxE and BbFoxE4 suggest that the ancestral FoxE class might have been recruited for the formation of thyroid-like region in a possible common ancestor of chordates. Furthermore, coexpression of FoxE4, Pax2/5/8, and TPO in the dorsolateral part of both ascidian and amphioxus endostyles suggests that genetic basis of the thyroid function was already in place before the vertebrate lineage. (c) 2005 Wiley-Liss, Inc.; The endostyle of invertebrate chordates is a pharyngeal organ that is thought to be homologous with the follicular thyroid of vertebrates. Although thyroid-like features such as iodine-concentrating and peroxidase activities are located in the dorsolateral part of both ascidian and amphioxus endostyles, the structural organization and numbers of functional units are different. To estimate phylogenetic relationships of each functional zone with special reference to the evolution of the thyroid, we have investigated, in ascidian and amphioxus, the expression patterns of thyroid-related transcription factors such as TTF-2/MoxE4 and Pax2/5/8, as well as the forkhead transcription factors FoxQ1 and FoxA. Comparative gene expression analyses depicted an overall similarity between ascidians and amphioxus endostyles, while differences in expression patterns of these genes might be specifically related to the addition or elimination of a pair of glandular zones. Expressions of Ci-FoxE and BbFoxE4 suggest that the ancestral FoxE class might have been recruited for the formation of thyroid-like region in a possible common ancestor of chordates. Furthermore, coexpression of FoxE4, Pax2/5/8, and TPO in the dorsolateral part of both ascidian and amphioxus endostyles suggests that genetic basis of the thyroid function was already in place before the vertebrate lineage. (c) 2005 Wiley-Liss, Inc.
学科主题	Anatomy & Morphology ; Developmental Biology
URL标识	查看原文
语种	英语
WOS记录号	WOS:000229892100034
公开日期	2010-11-18
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/1602]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Ogasawara, M, Chiba Univ, Fac Sci, Dept Biol, Chiba 2638522, Japan
作者单位	1.Chiba Univ, Fac Sci, Dept Biol, Chiba 2638522, Japan 2.Univ Reading, Sch Anim & Microbial Sci, Reading RG6 2AH, Berks, England 3.Hiroshima Univ, Grad Sch Sci, Biol Marine Lab, Hiroshima 730, Japan 4.Chinese Acad Sci, Inst Oceanol, Expt Marine Biol Lab, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Hiruta, J,Mazet, F,Yasui, K,et al. Comparative expression analysis of transcription factor genes in the endostyle of invertebrate chordates[J]. DEVELOPMENTAL DYNAMICS,2005,233(3):1031-1037.
APA	Hiruta, J,Mazet, F,Yasui, K,Zhang, PJ,Ogasawara, M,&Ogasawara, M, Chiba Univ, Fac Sci, Dept Biol, Chiba 2638522, Japan.(2005).Comparative expression analysis of transcription factor genes in the endostyle of invertebrate chordates.DEVELOPMENTAL DYNAMICS,233(3),1031-1037.
MLA	Hiruta, J,et al."Comparative expression analysis of transcription factor genes in the endostyle of invertebrate chordates".DEVELOPMENTAL DYNAMICS 233.3(2005):1031-1037.